Gene: WDR81
Official Full Name: WD repeat domain 81provided by HGNC
Gene Summary: This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play a role in endolysosomal trafficking. Mutations in this gene are associated with an autosomal recessive form of a syndrome exhibiting cerebellar ataxia, cognitive disability, and disequilibrium (CAMRQ2). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27793 | WDR81 Knockout cell line (HeLa) | Human | WDR81 | 1:3~1:6 | Negative | Online Inquiry |
KO27794 | WDR81 Knockout cell line (HCT 116) | Human | WDR81 | 1:2~1:4 | Negative | Online Inquiry |
KO27795 | WDR81 Knockout cell line (HEK293) | Human | WDR81 | 1:3~1:6 | Negative | Online Inquiry |
KO27796 | WDR81 Knockout cell line (A549) | Human | WDR81 | 1:3~1:4 | Negative | Online Inquiry |
WDR81 Gene Knockout Cell Lines are genetically engineered cell lines where the WDR81 gene has been inactivated through targeted gene editing techniques, such as CRISPR/Cas9. This innovative biological tool allows for the precise study of the functional roles of WDR81 in cellular processes, including its involvement in neuronal function, intracellular trafficking, and cellular stress responses.
These knockout cell lines exhibit a lack of WDR81 protein expression, providing researchers with a platform to investigate downstream signaling pathways and phenotypic changes that arise in the absence of this crucial protein. The key mechanisms underlying its action revolve around its roles in endosomal trafficking and regulation of synaptic transmission, making these cell lines vital for unraveling the complexities of neurobiology and related disorders.
The scientific significance of WDR81 Gene Knockout Cell Lines extends into various research domains, particularly in neuroscience and cellular biology. Their application can illuminate the underlying mechanisms of neurological disorders, enabling the discovery of new therapeutic targets and ultimately advancing the field of precision medicine. Additionally, they serve as powerful tools in drug discovery, toxicity testing, and functional genomics.
Compared to conventional models, such as whole organisms or non-specific cell lines, these knockout cell lines offer enhanced specificity and control over experimental conditions. Researchers can obtain reproducible results and derive insights that are directly attributable to the loss of WDR81 function, thus enabling more reliable conclusions about its biological importance.
For researchers and clinicians, the value of WDR81 Gene Knockout Cell Lines lies in their ability to provide a clear window into the functional consequences of gene inactivation with minimal confounding factors. This fosters a deeper understanding of gene function and its implications in health and disease.
At [Your Company Name], we are committed to advancing biological research through innovative genetic tools. With a robust portfolio of high-quality knockout cell lines, we empower scientists to explore the nuances of gene function with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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