Gene: WDR35
Official Full Name: WD repeat domain 35provided by HGNC
Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12610 | WDR35 Knockout cell line (HeLa) | Human | WDR35 | 1:3~1:6 | Negative | Online Inquiry |
KO12611 | WDR35 Knockout cell line (HCT 116) | Human | WDR35 | 1:2~1:4 | Negative | Online Inquiry |
KO12612 | WDR35 Knockout cell line (HEK293) | Human | WDR35 | 1:3~1:6 | Negative | Online Inquiry |
KO12613 | WDR35 Knockout cell line (A549) | Human | WDR35 | 1:3~1:4 | Negative | Online Inquiry |
WDR35 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene knockout technology to disrupt the function of the WDR35 gene. This gene is implicated in various critical biological processes, including cilia formation and function, which play an essential role in cellular signaling and the maintenance of tissue homeostasis. By creating a successful knockout of this gene, researchers can significantly advance their understanding of ciliary disorders and related pathologies.
The primary function of the WDR35 knockout cell lines revolves around elucidating the molecular mechanisms through which cilia affect cellular behaviors and responses. These cell lines enable researchers to investigate the effects of loss-of-function mutations on cellular pathways, providing valuable insights into the genetic underpinnings of diseases such as ciliopathies, which are characterized by dysfunctions in cilia and flagella. Utilization of these models can facilitate high-throughput screening for therapeutic compounds aimed at correcting or compensating for the loss of normal WDR35 function.
In terms of scientific importance, these cell lines are pivotal for academic and clinical research, particularly in the fields of genetics, cell biology, and pharmacology. As researchers work towards developing targeted therapies for conditions linked to the dysregulation of cilia, the availability of reliable WDR35 knockout models accelerates both in vitro and in vivo studies.
What sets our WDR35 Gene Knockout Cell Lines apart is their exceptional reliability and reproducibility, bolstered by rigorous validation processes. Unlike alternative models, our cell lines are generated using cutting-edge CRISPR/Cas9 technology, ensuring precise gene editing and consistent performance across multiple assays. This specificity translates into a significant reduction in off-target effects, enhancing experimental fidelity.
For researchers, the value of the WDR35 Gene Knockout Cell Lines lies in their capacity to provide clear, actionable insights into complex biological questions, enabling the development of innovative therapeutic strategies. With applications across multiple research paradigms, these cell lines serve as an indispensable tool in advancing our understanding of gene function and disease mechanisms.
Our company, with extensive expertise in cellular model development and gene editing technologies, is committed to providing superior biological products that empower scientists in their critical research endeavors. We take pride in our product offerings, which are designed to meet the highest standards of quality and innovation in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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