Gene: WDR11
Official Full Name: WD repeat domain 11provided by HGNC
Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12618 | WDR11 Knockout cell line (HeLa) | Human | WDR11 | 1:3~1:6 | Negative | Online Inquiry |
KO12619 | WDR11 Knockout cell line (HCT 116) | Human | WDR11 | 1:2~1:4 | Negative | Online Inquiry |
KO12620 | WDR11 Knockout cell line (HEK293) | Human | WDR11 | 1:3~1:6 | Negative | Online Inquiry |
KO12621 | WDR11 Knockout cell line (A549) | Human | WDR11 | 1:3~1:4 | Negative | Online Inquiry |
WDR11 Gene Knockout Cell Lines are genetically engineered cell lines in which the WDR11 gene has been inactivated through targeted gene editing techniques, such as CRISPR-Cas9. The WDR11 gene encodes a protein involved in various cellular functions, including regulation of signaling pathways and cellular stress responses. Its knockout facilitates the study of gene function, cellular mechanisms, and potentially therapeutic targets within a biological context.
These knockout cell lines provide researchers with a powerful tool to dissect the role of the WDR11 gene in cellular processes. By eliminating the expression of the WDR11 protein, users can investigate its implications in physiological conditions and disease states, particularly in areas such as neurobiology and developmental biology. The mechanisms by which WDR11 influences cellular behavior can be elucidated through functional assays, gene expression analysis, and cellular signaling investigations.
Research involving WDR11 has notable clinical relevance, particularly through its links to disorders related to metabolism and cellular dysfunction. By leveraging these knockout cell lines, researchers can develop and validate potential novel therapeutic interventions and gain insights that could translate into clinical applications.
Compared to alternative models, WDR11 Gene Knockout Cell Lines offer enhanced specificity and reliability in studying gene function. Traditional methods of gene inactivation may lead to off-target effects and incomplete gene disruption, while these precisely engineered cell lines provide a clean genetic background to observe the direct consequences of WDR11 inactivation.
The value of WDR11 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to facilitate high-quality, reproducible data, ultimately advancing our understanding of complex biological systems. As a leading provider of innovative biological products, our company stands at the forefront of genetic editing technologies, ensuring that our scientists have access to cutting-edge tools that enhance their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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