Gene: WASL
Official Full Name: WASP like actin nucleation promoting factorprovided by HGNC
Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33682 | WASL Knockout cell line (HeLa) | Human | WASL | 1:3~1:6 | Negative | Online Inquiry |
KO33683 | WASL Knockout cell line (HCT 116) | Human | WASL | 1:2~1:4 | Negative | Online Inquiry |
KO33684 | WASL Knockout cell line (HEK293) | Human | WASL | 1:3~1:6 | Negative | Online Inquiry |
KO33685 | WASL Knockout cell line (A549) | Human | WASL | 1:3~1:4 | Negative | Online Inquiry |
WASL Gene Knockout Cell Lines are specialized cellular models designed to enable detailed study and manipulation of the WASL gene, a crucial component in the regulation of actin cytoskeletal dynamics and cell signaling pathways. By employing CRISPR/Cas9 technology, these knockout cell lines effectively disrupt WASL gene expression, allowing researchers to investigate the gene's role in various biological processes, including cell migration, immune response, and cancer metastasis.
The primary function of WASL gene knockout cell lines is to provide a controlled environment for examining the significance of the WASL gene in cellular activities. The absence of WASL protein enables scientists to discern how its loss influences cellular motility and morphology, thereby elucidating underlying mechanisms in pathologies such as immunodeficiencies and tumors. The knockout lines can be utilized to conduct high-throughput screening, gene expression analyses, and functional assays that contribute to a deeper understanding of ACTB (actin) interactions.
The scientific importance of these cell lines is significant, particularly in research and clinical settings involving immunology, oncology, and developmental biology. Their application accelerates the identification of novel therapeutic targets and biomarkers, thereby advancing personalized medicine approaches. Moreover, when compared to alternative methods such as RNA interference or traditional gene editing techniques, WASL gene knockout cell lines provide a more stable gene inactivation, resulting in persistent phenotypic changes that are essential for long-term studies.
These cell lines represent an invaluable resource for researchers and clinicians seeking reliable models to explore the complexities of WASL functions. Their value lies in enabling cutting-edge research that drives scientific discovery, while providing insights that may lead to breakthroughs in disease treatment and prevention. Our company specializes in the development of high-quality biological products, ensuring the reliability and reproducibility of our WASL Gene Knockout Cell Lines, thus empowering researchers to advance their work with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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