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VTN Knockout Cell Lines

Gene: VTN

Official Full Name: vitronectinprovided by HGNC

Gene Summary: The protein encoded by this gene functions in part as an adhesive glycoprotein. Differential expression of this protein can promote either cell adhesion or migration as it links cells to the extracellular matrix through a variety of ligands. These ligands include integrins, plasminogen activator inhibitor-1, and urokinase plasminogen activator receptor. This secreted protein can be present in the plasma as a monomer or dimer and forms a multimer in the extracellular matrix of several tissues. This protein also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors. This protein can also promote extracellular matrix degradation and thus plays a role in tumorigenesis. It is involved in a variety of other biological processes such as the regulation of the coagulation pathway, wound healing, and tissue remodeling. The heparin-binding domain of this protein give it anti-microbial properties. It is also a lipid binding protein that forms a principal component of high density lipoprotein. [provided by RefSeq, Aug 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10120 VTN Knockout cell line (HeLa) Human VTN 1:3~1:6 Negative Online Inquiry
KO10121 VTN Knockout cell line (A549) Human VTN 1:3~1:4 Negative Online Inquiry

Background

VTN Gene Knockout Cell Lines are genetically engineered cell lines characterized by the targeted disruption or "knockout" of the VTN gene, which encodes the vitronectin protein, a key extracellular matrix component involved in cell adhesion, migration, and signaling. Designed for advanced biological research, these cell lines provide invaluable tools for studying gene function, elucidating molecular pathways, and observing the phenotypic consequences of gene loss in a controlled environment.

The principal mechanism of action in VTN gene knockout involves the use of CRISPR-Cas9 technology or other precise gene-editing techniques that introduce targeted double-strand breaks in the DNA, leading to insertions or deletions that result in gene inactivation. Consequently, researchers can investigate the roles of vitronectin in processes such as tumor progression, immune response, and cellular differentiation. The knockout of VTN is critical for understanding how variations in extracellular matrix components can affect cellular behavior and pathology.

In both research and clinical settings, the scientific importance of VTN Gene Knockout Cell Lines cannot be overstated. These tools facilitate studies in cancer biology, tissue engineering, and regenerative medicine by allowing scientists to dissect the role of vitronectin in various cellular responses. Furthermore, they have applications in drug discovery, as changes in cellular behavior can be monitored in response to therapeutic agents.

The advantages of VTN Gene Knockout Cell Lines over traditional models include enhanced specificity, greater reproducibility, and the ability to study loss-of-function effects in a homogenous cell population. This specificity reduces background variability, allowing for more reliable conclusions to be drawn from experiments.

For researchers and clinicians dedicated to advancing their understanding of cell biology and related fields, these knockout cell lines offer unparalleled insight and innovative approaches to experimental design. By enabling the dissection of the complex interactions governed by vitronectin, these tools provide a pathway for breakthroughs in understanding various diseases.

Our company specializes in the development and provision of high-quality biological products, including cutting-edge gene knockout models. With a commitment to scientific excellence and years of expertise in genetic engineering, we empower researchers to unlock the secrets of cellular processes for transformative impacts in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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