Gene: VTI1A
Official Full Name: vesicle transport through interaction with t-SNAREs 1Aprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24315 | VTI1A Knockout cell line (HeLa) | Human | VTI1A | 1:3~1:6 | Negative | Online Inquiry |
KO24316 | VTI1A Knockout cell line (HCT 116) | Human | VTI1A | 1:2~1:4 | Negative | Online Inquiry |
KO24317 | VTI1A Knockout cell line (HEK293) | Human | VTI1A | 1:3~1:6 | Negative | Online Inquiry |
KO24318 | VTI1A Knockout cell line (A549) | Human | VTI1A | 1:3~1:4 | Negative | Online Inquiry |
VTI1A Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the investigation of the VTI1A gene, a critical component involved in vesicular trafficking and membrane fusion processes within cells. These knockout cell lines have been meticulously created using cutting-edge CRISPR-Cas9 technology, allowing for the specific disruption of the VTI1A gene, enabling researchers to study the gene's functional role and its implications in various biological pathways.
The primary function of VTI1A is to mediate the fusion of transport vesicles with target membranes, a crucial step in the intracellular transport of proteins and lipids. By knocking out the VTI1A gene, researchers can observe the resultant alterations in cellular trafficking, enabling a better understanding of the mechanisms underlying key cellular processes, including neurotransmitter release, organelle communication, and the pathophysiology of various diseases.
These cell lines hold significant scientific importance, as they provide a model to explore the potential effects of VTI1A deficiency in both basic research contexts and clinical applications. For instance, studies have linked VTI1A with neurodegenerative diseases, making these knockout cell lines essential tools for discovering therapeutic targets and testing drug efficacy.
The advantages of VTI1A Gene Knockout Cell Lines over traditional methods, such as RNA interference or pharmacological inhibitors, lie in their specificity and stability. By entirely eliminating the VTI1A gene, researchers can avoid off-target effects and variable gene silencing, leading to more reproducible results. This specificity is critical when studying pathways directly influenced by VTI1A, ensuring the integrity of experimental outcomes.
For researchers and clinicians alike, the ability to utilize VTI1A knockout models translates into invaluable opportunities for gaining insights into neuronal function and mechanisms of disease. These cell lines represent a significant advancement in biological research, offering a robust platform for investigating gene functions and accelerating the development of therapies.
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Please note that all services are for research use only. Not intended for any clinical use.
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