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VPS41 Knockout Cell Lines

Gene: VPS41

Official Full Name: VPS41 subunit of HOPS complexprovided by HGNC

Gene Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27872 VPS41 Knockout cell line (HeLa) Human VPS41 1:3~1:6 Negative Online Inquiry
KO27873 VPS41 Knockout cell line (HCT 116) Human VPS41 1:2~1:4 Negative Online Inquiry
KO27874 VPS41 Knockout cell line (HEK293) Human VPS41 1:3~1:6 Negative Online Inquiry

Background

VPS41 Gene Knockout Cell Lines are specialized, genetically modified cell lines designed to facilitate research into the physiological roles and mechanisms of the VPS41 gene, which is implicated in endosomal trafficking and lysosomal function. The knockout of the VPS41 gene results in a loss of its associated protein function, providing researchers with a valuable tool for studying its contribution to cellular processes such as autophagy, vesicle transport, and cellular signaling pathways.

The key function of VPS41 involves its role as a vital component of the class C core complex, which is essential for the fusion of late endosomes with lysosomes. By utilizing these VPS41 knockout cell lines, researchers can investigate the downstream effects of VPS41 deficiency, including disruptions in protein sorting, accumulation of autophagic substrates, and alterations in cellular homeostasis. This makes the cell lines particularly beneficial for studies aimed at understanding metabolic disorders, neurodegenerative diseases, and cancer biology, where VPS41 dysfunction may play a pivotal role.

The scientific importance of VPS41 Gene Knockout Cell Lines extends beyond basic research; they hold potential for translational applications in identifying therapeutic targets and biomarkers. These cell lines enable high-throughput screening for drug candidates aimed at restoring normal cellular function in conditions associated with VPS41 dysregulation.

What sets our VPS41 Gene Knockout Cell Lines apart from other models is their rigorous validation process, ensured by CRISPR-Cas9 gene editing technology, resulting in precise and stable gene disruption. Additionally, we provide comprehensive support, including detailed characterization data and user-friendly protocols, assisting researchers in optimizing experimental conditions.

Investing in VPS41 Gene Knockout Cell Lines offers researchers and clinicians a reliable and efficient tool for unraveling the complexities of endosomal and lysosomal biology, ultimately paving the way for innovative therapies and improved understanding of disease mechanisms. With our company’s extensive experience in genetic modification technologies and commitment to quality, we are dedicated to equipping you with state-of-the-art biological products that advance your research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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