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VPS37C Knockout Cell Lines

Gene: VPS37C

Official Full Name: VPS37C subunit of ESCRT-Iprovided by HGNC

Gene Summary: VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12648 VPS37C Knockout cell line (HeLa) Human VPS37C 1:3~1:6 Negative Online Inquiry
KO12649 VPS37C Knockout cell line (HCT 116) Human VPS37C 1:2~1:4 Negative Online Inquiry
KO12650 VPS37C Knockout cell line (HEK293) Human VPS37C 1:3~1:6 Negative Online Inquiry
KO12651 VPS37C Knockout cell line (A549) Human VPS37C 1:3~1:4 Negative Online Inquiry

Background

VPS37C Gene Knockout Cell Lines represent a cutting-edge tool for biomedical research, specifically tailored for the study of autophagy and related cellular processes. These unique cell lines are genetically engineered to have the VPS37C gene completely inactivated, allowing researchers to delve deeper into the gene’s role in both normal cellular function and disease states. The VPS37C protein is a pivotal component of the ESCRT (endosomal sorting complexes required for transport) machinery, essential for the degradation of ubiquitinated proteins and viral assembly, making the knockout lines critical for understanding complex cellular dynamics.

The key function of VPS37C Gene Knockout Cell Lines lies in their ability to provide a controlled environment for the investigation of the cellular pathways influenced by VPS37C. Cellular mechanisms such as endosomal trafficking, receptor regulation, and protein degradation can be analyzed with precision, thereby revealing vital insights into processes like tumorigenesis, neurodegeneration, and various disorders linked to autophagic dysfunction. In both research and clinical settings, these cell lines offer an invaluable resource for studying disease mechanisms and testing therapeutic compounds.

One of the primary advantages of using VPS37C Gene Knockout Cell Lines is their specificity. Unlike alternative models that may introduce off-target effects or confounding variables, these knockout lines ensure that the effects observed are directly attributable to the absence of VPS37C. This level of precision is paramount for generating reliable data and fostering reproducible results, a key requirement in both academic and industrial research environments.

For researchers and clinicians focused on unraveling the complexities of cellular signaling and disease pathology, VPS37C Gene Knockout Cell Lines serve as an essential tool. They facilitate a deeper understanding of molecular interactions and provide a platform for the development of novel therapeutic strategies. The value of this product lies not only in its experimental utility but also in its potential to accelerate scientific discovery.

Our company prides itself on a robust portfolio of innovative biological products, equipped with state-of-the-art technologies and supported by a dedicated team of experts in genetic engineering and cell biology. We are committed to providing high-quality, reliable tools that empower researchers and clinicians to advance their work in molecular and cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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