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VPS36 Knockout Cell Lines

Gene: VPS36

Official Full Name: vacuolar protein sorting 36 homologprovided by HGNC

Gene Summary: This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23176 VPS36 Knockout cell line (HeLa) Human VPS36 1:3~1:6 Negative Online Inquiry
KO23177 VPS36 Knockout cell line (HCT 116) Human VPS36 1:2~1:4 Negative Online Inquiry
KO23178 VPS36 Knockout cell line (HEK293) Human VPS36 1:3~1:6 Negative Online Inquiry
KO23179 VPS36 Knockout cell line (A549) Human VPS36 1:3~1:4 Negative Online Inquiry

Background

VPS36 Gene Knockout Cell Lines represent a cutting-edge biological tool designed to facilitate the study of gene function and cellular mechanisms. These cell lines are engineered to have a specific knockout of the VPS36 gene, which encodes for a component of the endosomal sorting complexes required for transport (ESCRT). By creating a loss-of-function model, researchers can thoroughly investigate the role of VPS36 in various cellular processes, including membrane trafficking, receptor degradation, and the regulation of autophagy.

The key function of the VPS36 gene knockout is its ability to disrupt the normal cellular pathways associated with endosomal dynamics. This disruption allows scientists to observe the resultant phenotypic changes, providing insights into the molecular underpinnings of diseases linked to endosomal dysfunction, such as cancer and neurodegenerative disorders. Utilizing these cell lines, researchers can perform a variety of experiments to assess the impact of VPS36 depletion on cellular growth, signaling pathways, and interactions with other cellular structures, thereby offering a comprehensive view of its biological significance.

The scientific importance of VPS36 Gene Knockout Cell Lines cannot be overstated, as they are invaluable for both basic and applied research. In clinical settings, these models can aid in the identification of therapeutic targets and the development of new treatments. Comparatively, the VPS36 knockout cell lines stand out due to their specificity, reproducibility, and ease of use, allowing for high-precision studies that are often limited by alternative models.

For researchers and clinicians, the unique capability to dissect the VPS36-related pathways with these knockout lines presents opportunities for groundbreaking discoveries that can advance our understanding of various pathologies. This precision, combined with the ability to conduct high-throughput screenings, underscores the value of VPS36 Gene Knockout Cell Lines in both academic and pharmaceutical research contexts.

Our company is dedicated to providing high-quality, innovative biological products that empower scientists to push the boundaries of their research. With a robust portfolio of research tools backed by extensive expertise in genetic engineering, we aim to support the scientific community in their quest for knowledge and therapeutic breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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