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VGLL4 Knockout Cell Lines

Gene: VGLL4

Official Full Name: vestigial like family member 4provided by HGNC

Gene Summary: Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05288 VGLL4 Knockout cell line (HeLa) Human VGLL4 1:3~1:6 Negative Online Inquiry
KO05289 VGLL4 Knockout cell line (HCT 116) Human VGLL4 1:2~1:4 Negative Online Inquiry
KO05290 VGLL4 Knockout cell line (HEK293) Human VGLL4 1:3~1:6 Negative Online Inquiry
KO05291 VGLL4 Knockout cell line (A549) Human VGLL4 1:3~1:4 Negative Online Inquiry

Background

VGLL4 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the VGLL4 gene, a critical regulator in various biological pathways related to cancer development and progression. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines enable researchers to study the functional consequences of VGLL4 depletion, allowing for a deeper understanding of its role in cellular processes such as proliferation, differentiation, and apoptosis.

The primary function of VGLL4 is to act as a transcriptional co-regulator involved in Hippo signaling, which is pivotal in controlling organ size and cell contact inhibition. In the absence of VGLL4, cells may exhibit aberrant growth responses, making these knockout cell lines a valuable tool for dissecting the gene’s involvement in tumorigenesis and tissue homeostasis. Researchers can leverage these models to explore potential therapeutic targets and pathways for cancer treatment, significantly enhancing the translational impact of their studies.

The scientific importance of VGLL4 Gene Knockout Cell Lines cannot be overstated; they represent a pivotal resource in cancer research and regenerative medicine. By providing a controlled environment to study VGLL4's functional significance, these cell lines support the identification of novel biomarkers and therapeutic strategies, setting a foundation for advancing personalized medicine.

One of the unique advantages of the VGLL4 knockout lines is their ease of use in various experimental settings, ranging from high-throughput screenings to in-depth molecular analyses. Compared to other techniques that utilize less specific methods of gene inhibition, such as RNA interference, these knockout models ensure complete ablation of VGLL4, yielding more definitive results.

Researchers, clinicians, and pharmaceutical companies will find VGLL4 Gene Knockout Cell Lines invaluable due to their precision and the clarity they provide in experimental outcomes. The ability to robustly analyze the role of VGLL4 in health and disease translates into potential applications in discovering new treatments and understanding disease mechanisms.

Our company has extensive expertise in the development and provision of genetically modified cell lines, ensuring that you receive high-quality and reliable products tailored for your research needs. We are committed to advancing scientific discovery with innovative biological solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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