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VAPA Knockout Cell Lines

Gene: VAPA

Official Full Name: VAMP associated protein Aprovided by HGNC

Gene Summary: The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33438 VAPA Knockout cell line (HeLa) Human VAPA 1:3~1:6 Negative Online Inquiry
KO33439 VAPA Knockout cell line (HCT 116) Human VAPA 1:2~1:4 Negative Online Inquiry
KO33440 VAPA Knockout cell line (HEK293) Human VAPA 1:3~1:6 Negative Online Inquiry
KO33441 VAPA Knockout cell line (A549) Human VAPA 1:3~1:4 Negative Online Inquiry

Background

VAPA Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate the study of the VAPA (Vesicle-Associated Membrane Protein-Associated Protein A) gene's function and its role in various biological processes. These knockout cell lines are derived from commonly used mammalian cell lines and have undergone targeted gene editing using CRISPR-Cas9 technology, resulting in the complete ablation of the VAPA gene. This precise modification allows researchers to investigate the resultant phenotypic changes, enabling a deeper understanding of VAPA's contribution to cellular functions such as lipid metabolism, vesicular trafficking, and cell signaling pathways.

By utilizing these knockout cell lines, scientists can elucidate the pathways and interactions influenced by VAPA, providing insights that may extend to the development of novel therapeutic strategies for diseases linked to endosomal dysfunction, neurodegeneration, and metabolic disorders. The use of VAPA knockout models is instrumental in drug discovery, toxicology studies, and functional genomics, where understanding the loss of function is crucial for the evaluation of potential therapeutic targets.

Compared to standard cell lines, VAPA Gene Knockout Cell Lines offer unparalleled specificity and reproducibility, ensuring that researchers can achieve precise and reliable experimental results. Unlike other gene knockdown techniques which may result in partial or transient loss of gene function, our knockout lines provide a stable and consistent model for long-term studies and high-throughput screening.

For researchers and clinicians focusing on cellular mechanisms or therapeutic interventions, the availability of VAPA Gene Knockout Cell Lines is a significant advancement, enabling cutting-edge research with potential implications for both basic biology and clinical applications. With our company’s extensive expertise in genetic engineering and commitment to providing high-quality biological products, we are positioned to support scientific endeavors that could lead to transformative breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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