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USP46 Knockout Cell Lines

Gene: USP46

Official Full Name: ubiquitin specific peptidase 46provided by HGNC

Gene Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12727 USP46 Knockout cell line (HeLa) Human USP46 1:3~1:6 Negative Online Inquiry
KO12728 USP46 Knockout cell line (HCT 116) Human USP46 1:2~1:4 Negative Online Inquiry
KO12729 USP46 Knockout cell line (HEK293) Human USP46 1:3~1:6 Negative Online Inquiry
KO12730 USP46 Knockout cell line (A549) Human USP46 1:3~1:4 Negative Online Inquiry

Background

USP46 Gene Knockout Cell Lines are advanced cellular models engineered to lack the expression of the USP46 gene, a member of the ubiquitin-specific protease family. These knockout cell lines serve as invaluable tools for investigating the role of USP46 in cellular processes, including protein degradation, signaling pathways, and cellular responses to stress. By utilizing CRISPR-Cas9 gene editing technology, the product ensures precise and efficient gene disruption, enabling researchers to study the functional consequences of USP46 deficiency in various biological contexts.

The primary function of these cell lines is to serve as a platform for examining the impact of USP46 on critical biological mechanisms. USP46 is implicated in the regulation of several key pathways, including those involved in the cellular response to neurodegenerative diseases and oncogenesis. Researchers can harness the USP46 knockout cell lines to elucidate pathways affected by USP46 loss, contributing to a deeper understanding of its role in health and disease.

In research and clinical settings, these cell lines have significant applications in drug discovery, molecular biology, and translational research. Utilizing USP46 knockout models allows for the identification of potential therapeutic targets and the assessment of compounds aimed at modulating USP46-related pathways. Furthermore, their utility in basic research makes them accessible to a wide range of scientific inquiries.

Compared to traditional gene editing methods, the USP46 Gene Knockout Cell Lines offer researchers unparalleled specificity and efficiency, significantly reducing time and resources spent on developing knockout models. Additionally, the versatility of these cell lines enables their usage in various cellular contexts, providing a broad spectrum of experimental possibilities.

Ultimately, these cell lines are a vital asset for researchers, clinicians, and pharmaceutical companies looking to gain insights into gene function and its implications in disease states. With our company's expertise in molecular biology and commitment to providing high-quality research tools, we ensure that our products meet the rigorous standards of the scientific community, empowering discovery and innovation in biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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