Gene: USP15
Official Full Name: ubiquitin specific peptidase 15provided by HGNC
Gene Summary: This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05198 | USP15 Knockout cell line (HeLa) | Human | USP15 | 1:3~1:6 | Negative | Online Inquiry |
KO05199 | USP15 Knockout cell line (HCT 116) | Human | USP15 | 1:2~1:4 | Negative | Online Inquiry |
KO05200 | USP15 Knockout cell line (HEK293) | Human | USP15 | 1:3~1:6 | Negative | Online Inquiry |
KO05201 | USP15 Knockout cell line (A549) | Human | USP15 | 1:3~1:4 | Negative | Online Inquiry |
The USP15 Gene Knockout Cell Lines are genetically modified cellular models designed to study the function of the ubiquitin-specific protease 15 (USP15) gene, which plays a critical role in cellular processes such as protein degradation, cell signaling, and immune response regulation. By utilizing CRISPR-Cas9 technology, these cell lines have been engineered to completely disrupt the expression of USP15, allowing researchers to investigate the consequences of its absence on cellular behavior and biology.
These knockout cell lines serve as powerful tools for elucidating the mechanisms of USP15 in various biological contexts, including tumorigenesis, neurodegenerative diseases, and immune system modulation. Researchers can assess changes in protein stability, signaling pathways, and physiological responses that occur as a result of USP15 disruption, thereby contributing to a deeper understanding of its functional relevance in health and disease.
The scientific importance of the USP15 Gene Knockout Cell Lines is particularly highlighted in the field of drug discovery and development. By providing a robust platform for screening potential therapeutic agents that target USP15-mediated pathways, these cell lines can accelerate the identification of novel treatments. Moreover, they are invaluable in preclinical studies, allowing for the assessment of USP15 as a biomarker or therapeutic target in various malignancies and inflammatory conditions.
What sets the USP15 Gene Knockout Cell Lines apart from other models is their specificity for the USP15 gene, which eliminates off-target effects and enhances the reliability of experimental outcomes. They come equipped with comprehensive documentation and support, ensuring that users can efficiently integrate them into their research workflows. The cell lines are rigorously characterized and validated, providing researchers with confidence and reproducibility in their findings.
For researchers, clinicians, and pharmaceutical companies, the USP15 Gene Knockout Cell Lines offer significant value, enabling breakthroughs in understanding and addressing diseases tied to protein regulation and degradation pathways. With our commitment to advancing scientific knowledge, our company specializes in providing high-quality biological products that empower the research community to make impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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