Gene: UQCRC2
Official Full Name: ubiquinol-cytochrome c reductase core protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34839 | UQCRC2 Knockout cell line (HeLa) | Human | UQCRC2 | 1:3~1:6 | Negative | Online Inquiry |
KO34840 | UQCRC2 Knockout cell line (HCT 116) | Human | UQCRC2 | 1:2~1:4 | Negative | Online Inquiry |
KO34841 | UQCRC2 Knockout cell line (HEK293) | Human | UQCRC2 | 1:3~1:6 | Negative | Online Inquiry |
KO34842 | UQCRC2 Knockout cell line (A549) | Human | UQCRC2 | 1:3~1:4 | Negative | Online Inquiry |
UQCRC2 Gene Knockout Cell Lines are meticulously engineered biological reagents crucial for researchers investigating mitochondrial function and oxidative phosphorylation pathways. These cell lines feature a specific deletion of the UQCRC2 gene, which encodes a subunit of the mitochondrial ubiquinol-cytochrome c reductase complex III, an integral component of the electron transport chain. By employing precise genome editing techniques, such as CRISPR/Cas9, we have successfully generated knockout models that allow for the in-depth analysis of metabolic processes and energy production.
The primary function of UQCRC2 is to facilitate electron transfer in the respiratory chain, thereby playing a pivotal role in ATP synthesis. Knockout models enable scientists to dissect the contribution of UQCRC2 to mitochondrial health and disease, particularly in conditions such as neurodegeneration and cancer. By studying the phenotypic and physiological changes that arise from UQCRC2 disruption, researchers can unravel complex mitochondrial pathways and identify potential therapeutic targets.
In the realm of scientific research, the availability of UQCRC2 knockout cell lines stands out due to their capacity to model diseases of mitochondrial dysfunction, offering a valuable platform for drug screening and biomarker discovery. Compared to traditional wild-type models, these knockout lines present a unique advantage by providing clearer insights into the pathological roles of UQCRC2 in cellular metabolism.
For researchers and clinicians focused on mitochondrial disorders, these cell lines represent an indispensable tool in advancing our understanding of cellular energy dynamics. The value of UQCRC2 knockout cell lines lies not only in their innovative design but also in their utility as a reliable resource for exploring metabolic interventions and potential therapeutic avenues.
Our company prides itself on its commitment to providing high-quality, innovative biological products that support cutting-edge research. With a team of experienced scientists dedicated to advancing the life sciences, we strive to empower your research with reliable and precise tools like the UQCRC2 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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