Gene: UPK3B
Official Full Name: uroplakin 3Bprovided by HGNC
Gene Summary: UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25916 | UPK3B Knockout cell line (HeLa) | Human | UPK3B | 1:3~1:6 | Negative | Online Inquiry |
KO25917 | UPK3B Knockout cell line (HCT 116) | Human | UPK3B | 1:2~1:4 | Negative | Online Inquiry |
KO25918 | UPK3B Knockout cell line (A549) | Human | UPK3B | 1:3~1:4 | Negative | Online Inquiry |
UPK3B Gene Knockout Cell Lines are genetically modified cell lines specifically designed to investigate the role of the UPK3B gene in various biological processes and diseases. By utilizing CRISPR/Cas9 technology, these cell lines have been engineered to achieve precise deletion of the UPK3B gene, allowing researchers to study the resulting phenotypic changes in cellular behavior, signaling pathways, and interactions with other cellular components.
The key function of UPK3B Gene Knockout Cell Lines lies in their ability to provide a controlled system in which the absence of UPK3B can be meticulously examined. This gene is known to play a pivotal role in the formation of urothelial plaques and is implicated in bladder function and disorders. Through the observation of cellular adaptations to UPK3B knockout, researchers can explore critical mechanisms underlying bladder pathologies such as cancer, infections, and inflammatory conditions. These insights are essential in developing targeted therapies and understanding disease progression.
The scientific importance of UPK3B Gene Knockout Cell Lines extends to both basic research and translational applications in clinical settings. They facilitate the investigation of gene function, identification of potential biomarkers, and the development of novel therapeutic strategies. Additionally, these cell lines are a valuable tool for pharmaceutical companies in drug discovery processes, enabling the assessment of drug efficacy and safety profiles in a relevant genetic background.
What sets UPK3B Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene editing, coupled with robust validation processes to ensure reliability. Unlike generic cell lines, these knockout lines offer a streamlined approach for researchers looking to dissect the biological impacts of UPK3B depletion without the confounding variables present in wild-type cells.
For researchers, clinicians, and biotech professionals seeking to deepen their understanding of urothelial biology or develop innovative treatments, UPK3B Gene Knockout Cell Lines represent a powerful asset due to their potential to yield novel insights and enhance therapeutic development. Our company has extensive expertise in genetic engineering and a commitment to advancing cellular research technologies, providing high-quality and validated biological products to support the scientific community's endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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