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UCHL3 Knockout Cell Lines

Gene: UCHL3

Official Full Name: ubiquitin C-terminal hydrolase L3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04394 UCHL3 Knockout cell line (HeLa) Human UCHL3 1:3~1:6 Negative Online Inquiry
KO04395 UCHL3 Knockout cell line (HCT 116) Human UCHL3 1:2~1:4 Negative Online Inquiry
KO04396 UCHL3 Knockout cell line (HEK293) Human UCHL3 1:3~1:6 Negative Online Inquiry
KO04397 UCHL3 Knockout cell line (A549) Human UCHL3 1:3~1:4 Negative Online Inquiry

Background

UCHL3 Gene Knockout Cell Lines are advanced biological tools designed for the study of Ubiquitin C-terminal hydrolase L3 (UCHL3) function, a pivotal enzyme involved in protein homeostasis and ubiquitin-mediated signaling pathways. These cell lines are engineered to specifically disrupt the UCHL3 gene, allowing researchers to analyze the consequential phenotypic and biochemical effects arising from its absence, thereby elucidating its role in cellular processes such as protein degradation, signal transduction, and cellular stress responses.

The primary mechanism by which UCHL3 Gene Knockout Cell Lines operate is through gene editing techniques, such as CRISPR/Cas9, ensuring a precise and stable knockout of UCHL3. This intentional disruption facilitates the investigation of UCHL3’s involvement in various physiological conditions and diseases, including neurodegenerative disorders and cancer, where dysregulation of ubiquitin-proteasome pathways is often implicated. By providing a clear model for the absence of functional UCHL3, these cell lines enable researchers to dissect associated downstream effects and therapeutic targets.

From a scientific standpoint, UCHL3 Gene Knockout Cell Lines hold significant value in both fundamental research and therapeutic development settings. They can be utilized to validate drug candidates that influence UCHL3 activity or to study disease models in a more controlled environment, offering insights into its contribution to pathophysiology. Additionally, they serve as a platform for discovering novel biomarkers and treatment approaches.

The advantages of utilizing UCHL3 Gene Knockout Cell Lines over alternative models include their specificity and relevance, as well as their ability to produce consistent results across various experimental setups. Unlike alternative cell lines or models that may have ambiguous genetic backgrounds or compensatory mechanisms, these knockout lines provide a clean slate for investigation, minimizing confounding variables.

For researchers and clinicians alike, the UCHL3 Gene Knockout Cell Lines represent a unique and essential tool that enriches the understanding of UCHL3’s biological functions. With a commitment to quality and scientific rigor, our company specializes in the development and supply of high-fidelity genetic models, ensuring that our offerings support your research goals with precision and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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