Gene: UBXN8
Official Full Name: UBX domain protein 8provided by HGNC
Gene Summary: p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34355 | UBXN8 Knockout cell line (HeLa) | Human | UBXN8 | 1:3~1:6 | Negative | Online Inquiry |
KO34356 | UBXN8 Knockout cell line (HCT 116) | Human | UBXN8 | 1:2~1:4 | Negative | Online Inquiry |
KO34357 | UBXN8 Knockout cell line (HEK293) | Human | UBXN8 | 1:3~1:6 | Negative | Online Inquiry |
KO34358 | UBXN8 Knockout cell line (A549) | Human | UBXN8 | 1:3~1:4 | Negative | Online Inquiry |
UBXN8 Gene Knockout Cell Lines represent a sophisticated tool for researchers aiming to study the biological implications of UBXN8. These cell lines have been engineered to lack the UBXN8 gene, providing a unique platform for assessing the gene's role in cellular processes such as protein degradation, DNA repair, and cellular stress responses. By utilizing CRISPR/Cas9 technology, these knockout models ensure specific and efficient targeting, allowing for the thorough investigation of UBXN8's function in various pathways.
The primary function of the UBXN8 Gene Knockout Cell Lines lies in their ability to mimic the physiological effects of UBXN8 deficiency. Researchers can observe changes in cellular behavior, including alterations in cell proliferation, apoptosis, and signaling pathways, ultimately enhancing the understanding of UBXN8's contribution to various diseases, particularly cancer and neurodegenerative disorders. Furthermore, these cell lines serve as an excellent system for drug screening, where potential therapeutic compounds can be evaluated against the altered cellular environment caused by the knockout.
Scientifically, the applicability of UBXN8 Gene Knockout Cell Lines extends to both basic and applied research realms. In clinical settings, these models can facilitate preclinical studies aimed at uncovering new therapeutic targets and developing personalized medicine approaches. Their high utility across fields like oncology and molecular biology underscores their importance in advancing current knowledge and therapeutic strategies.
Compared to traditional gene editing methods, the UBXN8 Gene Knockout Cell Lines offer higher precision, efficiency, and reproducibility, dramatically reducing the time and resources spent on experimental setups. Additionally, as knockout models specifically eliminate the UBXN8 gene, they minimize off-target effects that can confound results.
For researchers and clinicians seeking reliable and innovative tools to explore gene function, the UBXN8 Gene Knockout Cell Lines provide an unparalleled advantage. These cell lines are not merely research instruments; they embody a commitment to cutting-edge scientific inquiry and the advancement of medical knowledge. Our company is dedicated to providing high-quality biological products that empower researchers in their quest for innovation and discovery. With our expertise and focus on excellence, we are here to support your journey toward scientific breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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