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UACA Knockout Cell Lines

Gene: UACA

Official Full Name: uveal autoantigen with coiled-coil domains and ankyrin repeatsprovided by HGNC

Gene Summary: This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12896 UACA Knockout cell line (HeLa) Human UACA 1:3~1:6 Negative Online Inquiry
KO12897 UACA Knockout cell line (HCT 116) Human UACA 1:2~1:4 Negative Online Inquiry
KO12898 UACA Knockout cell line (HEK293) Human UACA 1:3~1:6 Negative Online Inquiry
KO12899 UACA Knockout cell line (A549) Human UACA 1:3~1:4 Negative Online Inquiry

Background

UACA Gene Knockout Cell Lines represent a significant advancement in the study of gene function and regulation, utilizing the CRISPR/Cas9 genome editing technology. These engineered cell lines have been specifically modified to disable the UACA gene, facilitating researchers in investigating the molecular mechanisms underpinning various biological processes and diseases. By removing the UACA gene’s influence, scientists are able to observe resultant phenotypic changes, thus elucidating the gene's role in oncogenesis, cell signaling pathways, and other critical cellular functions.

The primary mechanism of action involves targeted editing of the genomic sequence associated with the UACA gene, leading to frameshift mutations that effectively disrupt normal gene expression. Researchers can exploit these modifications to assess the impact of UACA absence on cellular characteristics, such as proliferation, differentiation, and apoptosis. Given the importance of UACA in several disease contexts, including cancer, these knockout cell lines serve as invaluable tools for drug testing, biomarker discovery, and basic biological research.

Scientific importance is underscored by the application of UACA Gene Knockout Cell Lines in both academic and pharmaceutical research settings, enabling in-depth studies on gene function and therapeutic target validation. The unique advantages of these cell lines include their high consistency and reproducibility compared to other models, which often exhibit genetic variability that can confound experimental results.

For researchers and clinicians, the ability to utilize a standardized, high-quality model such as UACA Gene Knockout Cell Lines greatly enhances experimental accuracy and supporting data reliability. These lines not only streamline the research process but also expedite the transition from basic discoveries to practical applications in therapeutic development.

At [Your Company Name], we pride ourselves on extensive expertise in genetic engineering and cell line development, ensuring that our UACA Gene Knockout Cell Lines deliver the highest quality for your research needs. With our commitment to innovation and accuracy, we provide solutions that empower breakthroughs in understanding gene function and disease mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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