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TUSC3 Knockout Cell Lines

Gene: TUSC3

Official Full Name: tumor suppressor candidate 3provided by HGNC

Gene Summary: This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34351 TUSC3 Knockout cell line (HeLa) Human TUSC3 1:3~1:6 Negative Online Inquiry
KO34352 TUSC3 Knockout cell line (HCT 116) Human TUSC3 1:2~1:4 Negative Online Inquiry
KO34353 TUSC3 Knockout cell line (HEK293) Human TUSC3 1:3~1:6 Negative Online Inquiry
KO34354 TUSC3 Knockout cell line (A549) Human TUSC3 1:3~1:4 Negative Online Inquiry

Background

TUSC3 Gene Knockout Cell Lines are genetically engineered cell lines in which the TUSC3 gene has been specifically inactivated, allowing researchers to study the functional role of this gene in various biological processes. The TUSC3 gene, known for its involvement in the regulation of cellular stress responses and its role in the biogenesis of N-linked glycoproteins, plays a crucial role in maintaining cellular homeostasis. By utilizing TUSC3 knockout models, scientists can investigate the impact of its loss on various cellular functions, including cell proliferation, apoptosis, and signaling pathways, thereby elucidating its potential implications in cancer and other diseases.

The primary mechanism of action for these cell lines involves the disruption of TUSC3's normal function, leading to altered glycosylation patterns and potentially affecting downstream signaling cascades. This alteration allows for a more significant understanding of disease pathology, particularly in cancer research where TUSC3 has been implicated. Scientists can leverage these knockout models for drug screening, mechanistic studies, and the development of therapeutic strategies aimed at targeting glycosylation-related pathways.

The scientific importance of TUSC3 Gene Knockout Cell Lines extends to a variety of research and clinical applications. They are invaluable tools for those researching genetic disorders, cancer biology, and biochemical pathways involved in cellular stress responses. Compared to other gene knockout models, our TUSC3 knockout cell lines are characterized by their high specificity and reliability, providing researchers with consistent and reproducible results. Additionally, the ease of use and inherent flexibility of these models allow for high-throughput screening and targeted gene editing experiments, making them an optimal choice for cutting-edge research.

For researchers and clinicians, the value of TUSC3 Gene Knockout Cell Lines lies in their ability to facilitate novel insights into therapeutic targets, enhancing the understanding of disease mechanisms and supporting the development of innovative treatments. Our commitment to quality and precision in developing these cell lines is backed by our extensive experience in genetic engineering and cell biology, positioning us as a trusted partner in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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