Gene: TRPC4
Official Full Name: transient receptor potential cation channel subfamily C member 4provided by HGNC
Gene Summary: This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00490 | TRPC4 knockout cell line (HeLa) | Human | TRPC4 | 1:3~1:6 | Negative | Online Inquiry |
TRPC4 Gene Knockout Cell Lines are genetically engineered cells that have been specifically modified to disrupt the expression of the transient receptor potential cation channel 4 (TRPC4) gene. This product is crucial for understanding the physiological and pathological roles of TRPC4 in various biological processes, including calcium signaling, cell proliferation, and neuronal function. By knocking out the TRPC4 gene, researchers can elucidate its contribution to diverse cellular functions and its impact on disease mechanisms.
The primary function of TRPC4 Gene Knockout Cell Lines lies in their ability to facilitate the study of TRPC4-related pathways without the confounding effects of its normal expression. These cell lines work by employing advanced genome-editing technologies, such as CRISPR-Cas9, to create precise deletions or mutations in the TRPC4 gene. This knockout allows for the systematic investigation of TRPC4's roles in various contexts, including its involvement in cardiovascular health, neuronal excitability, and sensory perception.
The scientific significance of TRPC4 Gene Knockout Cell Lines is vast, with applications ranging from basic research to translational studies aimed at developing therapeutic interventions. In research settings, these cell lines can be employed to investigate how TRPC4 influences cell communication and signaling pathways, contributing to our understanding of diseases such as hypertension, cancer, and neurodegenerative conditions. Clinically, insights gained from studies using these knockout cell lines can inform the development of targeted therapies.
What sets our TRPC4 Gene Knockout Cell Lines apart from alternative products is their reliability and reproducibility. We use rigorously validated gene-editing methods to ensure that the knockout is complete and consistent across cell batches, offering researchers a dependable tool for their experiments. Additionally, our cell lines are available in multiple background strains, allowing for greater experimental flexibility tailored to specific research needs.
Researchers and clinicians can significantly benefit from the use of TRPC4 Gene Knockout Cell Lines as they provide a clear and accurate model for dissecting the intricate roles of TRPC4. Their application not only supports the advancement of scientific knowledge but also paves the way for potential breakthroughs in medical treatments.
Our company prides itself on its expertise in providing high-quality biologically-related products, and we are committed to supporting the scientific community with innovative tools that drive exploration and discovery in cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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