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TRIP4 Knockout Cell Lines

Gene: TRIP4

Official Full Name: thyroid hormone receptor interactor 4provided by HGNC

Gene Summary: This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00318 TRIP4 Knockout cell line (HeLa) Human TRIP4 1:3~1:6 Negative Online Inquiry
KO33328 TRIP4 Knockout cell line (HCT 116) Human TRIP4 1:2~1:4 Negative Online Inquiry
KO33329 TRIP4 Knockout cell line (HEK293) Human TRIP4 1:3~1:6 Negative Online Inquiry
KO33330 TRIP4 Knockout cell line (A549) Human TRIP4 1:3~1:4 Negative Online Inquiry

Background

TRIP4 Gene Knockout Cell Lines represent a significant advancement in the toolkit available for molecular biology and genetic research. These cell lines have been specifically engineered to eliminate the TRIP4 gene, which encodes a protein known to play critical roles in cellular processes, including transcriptional regulation and cellular growth. By utilizing CRISPR-Cas9 genome-editing technology, these knockout cell lines serve as a powerful resource for studying the specific functions of the TRIP4 gene in various biological contexts.

The primary function of the TRIP4 gene product is to participate in the regulation of transcriptional processes and signal transduction. By facilitating interactions between various transcription factors and co-regulators, TRIP4 influences gene expression patterns that can affect cellular behavior. The knockout of this gene allows researchers to dissect the pathways and mechanisms that are modulated by TRIP4, contributing to a greater understanding of signaling cascades and cellular responses to environmental stimuli.

From a scientific perspective, TRIP4 Gene Knockout Cell Lines provide invaluable insights into a range of applications, including cancer research, drug development, and studies of gene regulation. In clinical settings, understanding the role of TRIP4-associated pathways could lead to the identification of new therapeutic targets, enhancing the treatment of various diseases. The ability to work with a cell line devoid of TRIP4 opens new avenues for researchers to explore its role in disease modeling and therapeutic interventions.

What sets TRIP4 Gene Knockout Cell Lines apart from traditional cell lines is their specificity and reliability, ensuring consistent results across experiments. Unlike other methods, such as siRNA knockdowns, which can result in transient gene silencing, these stable knockout lines maintain the gene's absence long-term, allowing for repeated and thorough investigations into the gene's function.

In summary, TRIP4 Gene Knockout Cell Lines are an essential resource for researchers seeking to understand the multifaceted roles of the TRIP4 gene. Their application lends significant value to both academic and clinical research, enabling the investigation of crucial cellular processes and aiding in the development of novel therapeutic strategies. Our company's commitment to providing high-quality, precision-engineered biological products ensures that researchers have the best tools at their disposal for advancing knowledge in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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