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TRIM32 Knockout Cell Lines

Gene: TRIM32

Official Full Name: tripartite motif containing 32provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30097 TRIM32 Knockout cell line (HeLa) Human TRIM32 1:3~1:6 Negative Online Inquiry
KO30098 TRIM32 Knockout cell line (HCT 116) Human TRIM32 1:2~1:4 Negative Online Inquiry
KO30099 TRIM32 Knockout cell line (HEK293) Human TRIM32 1:3~1:6 Negative Online Inquiry
KO30100 TRIM32 Knockout cell line (A549) Human TRIM32 1:3~1:4 Negative Online Inquiry

Background

TRIM32 Gene Knockout Cell Lines are specialized cellular models developed through targeted gene editing techniques to disrupt the TRIM32 gene, a critical player in various cellular processes, including ubiquitination, gene expression regulation, and immune response modulation. The generated cell lines allow researchers to investigate the functional consequences of TRIM32 deficiency, providing insights into its role in muscle development, neuronal function, and potential implications in diseases, such as muscular dystrophy and several neurodegenerative disorders.

The principal function of TRIM32 involves its E3 ubiquitin ligase activity, which tags proteins for degradation by the proteasome, thus regulating their stability and function. By knocking out the TRIM32 gene, these cell lines exhibit altered signaling pathways, enabling scientists to elucidate the precise cellular mechanisms that TRIM32 influences. This functional analysis is pivotal in understanding how TRIM32 aberrations contribute to disease pathogenesis and presents opportunities for therapeutic intervention.

The scientific importance of TRIM32 Gene Knockout Cell Lines extends beyond basic research; they offer significant applications in drug discovery, biomarker identification, and gene therapy studies. Researchers can utilize these models to test pharmacological agents targeting pathways affected by TRIM32 loss and to explore the potential for gene editing therapies in restoring normal function.

What sets TRIM32 Gene Knockout Cell Lines apart from alternative models is their precision and verified efficacy. Our cell lines are rigorously validated for genetic modification and functional relevance, ensuring they provide reliable data for your experimental needs. Additionally, these knockout lines facilitate the reproducibility of results, a crucial element for advancing research.

By integrating TRIM32 Gene Knockout Cell Lines into your research arsenal, you gain a powerful tool for understanding complex cellular dynamics and contribute to the frontier of biomedical science. Our company specializes in developing high-quality biological models, ensuring robust and reproducible products tailored to meet the research needs of scientists and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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