Gene: TRIB2
Official Full Name: tribbles pseudokinase 2provided by HGNC
Gene Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27303 | TRIB2 Knockout cell line (HeLa) | Human | TRIB2 | 1:3~1:6 | Negative | Online Inquiry |
KO27304 | TRIB2 Knockout cell line (HCT 116) | Human | TRIB2 | 1:2~1:4 | Negative | Online Inquiry |
KO27305 | TRIB2 Knockout cell line (HEK293) | Human | TRIB2 | 1:3~1:6 | Negative | Online Inquiry |
TRIB2 Gene Knockout Cell Lines are highly specialized genetic models engineered to eliminate the expression of the TRIB2 gene, a critical regulator in various biological processes such as cell survival, differentiation, and proliferation. By using advanced CRISPR-Cas9 technology, these cell lines provide a powerful tool to study the functional consequences of TRIB2 in cellular mechanisms, enabling researchers to elucidate its role in cancer, metabolic disorders, and immune responses.
The TRIB2 protein is known to act as a scaffold protein that interacts with several signaling pathways, including MAPK and NF-kB pathways, thereby influencing the balance between cell growth and apoptosis. By removing TRIB2 functionality, scientists can observe subsequent alterations in cell metabolism, gene expression profiles, and signaling cascades. This knockout capability allows for a comprehensive understanding of TRIB2’s contribution to disease biology and therapeutic responses.
From a research perspective, TRIB2 Gene Knockout Cell Lines hold immense significance, providing a validated model for investigating tumorigenesis and the development of targeted therapies. Their applications span basic research to pharmaceutical development, where understanding the gene's role could lead to novel interventions for diseases associated with TRIB2 dysregulation.
This product stands out from alternative cell models by offering ready-to-use cell lines that save valuable time in experimental design and implementation. Employing these knockout lines reduces the variability associated with traditional gene editing techniques, ensuring more reproducible and reliable results.
For researchers and clinicians, the TRIB2 Gene Knockout Cell Lines are an invaluable asset in advancing the understanding of oncogenesis and developing precision medicine strategies. By harnessing the insights gained from these models, users can contribute to groundbreaking discoveries that drive forward the field of molecular biology and therapeutic innovation.
At [Your Company Name], we pride ourselves on our commitment to providing cutting-edge biological tools that empower scientific inquiry and clinical advancement. Our expertise in cell line development and genetic engineering ensures that our products meet the highest standards of quality and efficacy, enabling researchers to achieve their goals with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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