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TRAPPC14 Knockout Cell Lines

Gene: TRAPPC14

Official Full Name: trafficking protein particle complex subunit 14provided by HGNC

Gene Summary: Enables alpha-tubulin binding activity. Involved in cilium assembly and regulation of cell population proliferation. Located in several cellular components, including microtubule cytoskeleton; midbody; and plasma membrane. Part of TRAPPII protein complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13075 TRAPPC14 Knockout cell line (HeLa) Human TRAPPC14 1:3~1:6 Negative Online Inquiry
KO13076 TRAPPC14 Knockout cell line (HCT 116) Human TRAPPC14 1:2~1:4 Negative Online Inquiry
KO13077 TRAPPC14 Knockout cell line (HEK293) Human TRAPPC14 1:3~1:6 Negative Online Inquiry
KO13078 TRAPPC14 Knockout cell line (A549) Human TRAPPC14 1:3~1:4 Negative Online Inquiry

Background

TRAPPC14 Gene Knockout Cell Lines are genetically engineered cell models that facilitate the study of TRAPPC14, a protein implicated in trafficking and signal transduction pathways. These cell lines are designed to exhibit a specific gene disruption, allowing researchers to explore the cellular functions modulated by TRAPPC14. By using CRISPR-Cas9 technology, these knockout cell lines provide a powerful framework for dissecting the mechanistic roles of TRAPPC14 in various cellular processes, from vesicle transport to the regulation of signaling pathways.

The primary function of the TRAPPC14 Gene Knockout Cell Lines is to enable the detailed investigation of TRAPPC14’s involvement in cell biology, particularly its effects on endoplasmic reticulum (ER) function and Golgi apparatus dynamics. The absence of TRAPPC14 allows scientists to observe phenotypic alterations, providing insights into how TRAPPC14 contributes to cellular homeostasis and its potential role in disease contexts such as cancer and neurodegeneration.

In scientific research, these cell lines are invaluable for elucidating the complex pathways regulated by TRAPPC14 and can provide a model for drug discovery, offering insights into therapeutic interventions targeting related pathways. They are particularly important in translational research, where understanding the genetic basis of diseases can lead to novel treatment approaches.

One of the significant advantages of the TRAPPC14 Gene Knockout Cell Lines is their specificity and reliability. Unlike traditional methods of gene knockdown, the CRISPR-Cas9 gene editing ensures a stable and targeted disruption of the gene, thus providing consistent results across experiments. Additionally, these cell lines can be used in combination with various bioassays, making them versatile tools in both laboratory and clinical research settings.

For researchers and clinicians striving to advance their understanding of cellular mechanisms and potential therapeutic targets, the TRAPPC14 Gene Knockout Cell Lines offer an unparalleled resource. With a firm commitment to innovation in the field of genetic research, our company specializes in supplying high-quality biological materials that empower scientific discovery and facilitate breakthroughs in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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