Gene: TPRG1L
Official Full Name: tumor protein p63 regulated 1 likeprovided by HGNC
Gene Summary: Predicted to enable calmodulin binding activity and identical protein binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27086 | TPRG1L Knockout cell line (HeLa) | Human | TPRG1L | 1:3~1:6 | Negative | Online Inquiry |
KO27087 | TPRG1L Knockout cell line (HCT 116) | Human | TPRG1L | 1:2~1:4 | Negative | Online Inquiry |
KO27088 | TPRG1L Knockout cell line (HEK293) | Human | TPRG1L | 1:3~1:6 | Negative | Online Inquiry |
KO27089 | TPRG1L Knockout cell line (A549) | Human | TPRG1L | 1:3~1:4 | Negative | Online Inquiry |
TPRG1L Gene Knockout Cell Lines are specialized cellular models where the TPRG1L gene has been selectively disrupted, providing researchers with a powerful tool to investigate the biological roles and intricate mechanisms associated with this gene. TPRG1L, or Tumor Protein p53 Regulator 1-Like, has emerged as a critical factor in various cellular processes, including apoptosis, cell cycle regulation, and response to stress. By utilizing these knockout cell lines, researchers can delve into the specific contributions of TPRG1L in pathophysiological conditions, including cancer and neurodegenerative diseases.
The primary function of TPRG1L knockout cell lines lies in their ability to facilitate the study of gene function through loss-of-function experiments. This allows scientists to observe phenotypic changes, alterations in signaling pathways, and gene expression patterns that occur when the TPRG1L gene is non-functional. The precise mechanisms by which TPRG1L influences cellular behavior can be elucidated, yielding insights that are essential not only for fundamental research but also for potential translation into therapeutic strategies.
In the context of scientific importance, TPRG1L knockout cell lines contribute significantly to ongoing research in understanding tumorigenesis and cellular resilience. Their applications in drug discovery and development are particularly noteworthy, as they can serve as platforms for screening compounds that may reactivate or compensate for the loss of TPRG1L function, ultimately leading to innovative therapeutic approaches.
Compared to traditional wild-type cell lines, TPRG1L knockout models offer unique advantages, such as the elimination of confounding genetic variability and the ability to model specific diseases that are influenced by TPRG1L expression levels. This specificity enhances the reliability and reproducibility of experimental outcomes.
Researchers, clinicians, and industry professionals seeking to pioneer advancements in genetics and molecular biology will find TPRG1L Gene Knockout Cell Lines invaluable for their studies. The potential for generating novel insights into cellular processes and disease mechanisms ensures that these cell lines are a worthwhile investment for anyone dedicated to pushing the boundaries of scientific knowledge.
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