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TP73 Knockout Cell Lines

Gene: TP73

Official Full Name: tumor protein p73provided by HGNC

Gene Summary: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08524 TP73 Knockout cell line (HeLa) Human TP73 1:3~1:6 Negative Online Inquiry
KO08525 TP73 Knockout cell line (HCT 116) Human TP73 1:2~1:4 Negative Online Inquiry
KO08526 TP73 Knockout cell line (HEK293) Human TP73 1:3~1:6 Negative Online Inquiry

Background

TP73 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to disrupt the expression of the TP73 gene, which is associated with various cellular processes, including apoptosis, cell cycle regulation, and neural development. These cell lines serve as invaluable tools for researchers to dissect the roles of TP73 in physiological and pathological conditions.

The primary function of TP73 knockout cell lines lies in their ability to facilitate studies on the gene’s role in cancer biology, neurodegenerative diseases, and developmental disorders. By eliminating TP73 expression, researchers can investigate the consequences on cellular behavior, such as proliferation, survival, differentiation, and response to environmental stressors. The mechanisms underlying these alterations can further aid in elucidating the biological pathways influenced by TP73, thereby advancing our understanding of its involvement in disease mechanisms.

The scientific importance of TP73 knockout cell lines resides in their diverse applications across research and clinical settings. These models can be employed to explore potential therapeutic targets in cancers that involve dysregulation of the TP73 pathway. They are also instrumental in drug screening and development, helping to identify compounds that can specifically modulate the activity of TP73 and its downstream effects.

Compared to alternative models, TP73 knockout cell lines offer several unique advantages, including the specificity of gene disruption, consistency in experimental outcomes, and ease of use. They provide a robust platform for high-throughput studies and are compatible with various assays, providing flexibility for researchers in multiple disciplines.

The value of TP73 gene knockout cell lines is particularly significant for researchers and clinicians focused on unraveling complex disease mechanisms and developing novel therapeutic strategies. Their insights can drive discoveries that lead to more effective treatment modalities.

With a commitment to advancing scientific knowledge, our company specializes in providing high-quality genetic models that empower researchers with the tools needed to push the boundaries of biomedical research. We are dedicated to supporting the scientific community with reliable and innovative products that enhance experimental rigor and efficiency.

Please note that all services are for research use only. Not intended for any clinical use.

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