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TP63 Knockout Cell Lines

Gene: TP63

Official Full Name: tumor protein p63provided by HGNC

Gene Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02594 TP63 Knockout cell line (A549) Human TP63 1:3~1:4 Negative Online Inquiry

Background

TP63 Gene Knockout Cell Lines are specialized cellular models used in biological research that enable scientists to investigate the function and regulation of the TP63 gene, a member of the p53 family involved in numerous essential cellular processes including development, differentiation, and tumor suppression. By genetically knocking out the TP63 gene, these cell lines facilitate the study of phenotypic changes and molecular pathways that are disrupted in various diseases, particularly in cancers and developmental disorders.

The primary mechanism behind these knockout cell lines involves CRISPR-Cas9 gene editing technology, which allows for precise alterations in the genomic sequence of the TP63 gene. This technological innovation not only guarantees effective gene disruption but also streamlines the generation of genetically modified organisms, providing a reliable platform for functional studies. Researchers can utilize these cell lines to elucidate TP63's role in epithelial development and apoptosis, shedding light on tumorigenesis and potential therapeutic intervention points.

The scientific importance of TP63 Gene Knockout Cell Lines is profound, particularly in translational research where understanding tumor suppressor genes is critical for drug development and personalized medicine. These models serve as valuable tools in both basic and applied research, underpinning studies aimed at developing targeted therapies for cancer treatment and regenerative medicine.

What sets our TP63 Gene Knockout Cell Lines apart from alternatives is their consistent performance, validated phenotypic characteristics, and user-friendly protocols, which reduce time and resource expenditures in research endeavors. Additionally, they are produced under stringent quality control, ensuring high purity and viability for experimental applications.

These cell lines represent a significant asset for researchers and clinicians who seek to advance their understanding of cancer biology and genetics. Investing in TP63 Gene Knockout Cell Lines will not only enhance your laboratory's capabilities but also contribute to impactful findings that may shape future medical therapies.

Our company's expertise in gene editing and cell line development positions us at the forefront of biotechnological innovation, providing researchers with precise tools necessary for groundbreaking discoveries in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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