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TOR1A Knockout Cell Lines

Gene: TOR1A

Official Full Name: torsin family 1 member Aprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07003 TOR1A Knockout cell line (HeLa) Human TOR1A 1:3~1:6 Negative Online Inquiry
KO07004 TOR1A Knockout cell line (HCT 116) Human TOR1A 1:2~1:4 Negative Online Inquiry
KO07005 TOR1A Knockout cell line (HEK293) Human TOR1A 1:3~1:6 Negative Online Inquiry
KO07006 TOR1A Knockout cell line (A549) Human TOR1A 1:3~1:4 Negative Online Inquiry

Background

TOR1A Gene Knockout Cell Lines are specifically engineered cellular models utilized to study the functions of the TOR1A gene, which encodes the torsin A protein, essential for various neuronal processes. These knockout cell lines have been developed using advanced CRISPR-Cas9 gene editing technology, resulting in cells that lack functional TOR1A, allowing researchers to explore the gene's role in cellular homeostasis, stress response, and neurodegenerative disorders, especially in the context of Dystonia.

The mechanism through which these cell lines operate involves the disruption of the TOR1A gene, leading to alterations in cellular signaling pathways that are crucial for maintaining synaptic integrity and mitochondrial function. By using these knockout models, researchers can better understand the molecular underpinnings of diseases associated with impaired torsin A function, facilitating the discovery of potential therapeutic targets. In both research and clinical settings, TOR1A Gene Knockout Cell Lines provide invaluable insights into pathways involved in dystonia and other neurological disorders.

What sets TOR1A Gene Knockout Cell Lines apart from alternative models is their specific and precise genetic alteration, which allows for reproducible and reliable experimental outcomes. Unlike traditional methods that may produce mixed results or rely on pharmacological agents to mimic gene function loss, these cell lines offer a controlled environment to observe the effects of TOR1A deficiency directly.

This product represents immense value to researchers and clinicians seeking to deepen their understanding of the TOR1A gene's role in health and disease. By leveraging these cell lines, users can save time and resources, while accelerating the pace of discovery in neurobiology.

Our company specializes in providing high-quality biological products and innovative solutions tailored to the needs of research laboratories and clinical institutions. With a focus on cutting-edge technology and rigorous quality control, we are committed to supporting scientific advancement in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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