Gene: TMTC2
Official Full Name: transmembrane O-mannosyltransferase targeting cadherins 2provided by HGNC
Gene Summary: The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13144 | TMTC2 Knockout cell line (HeLa) | Human | TMTC2 | 1:3~1:6 | Negative | Online Inquiry |
KO13145 | TMTC2 Knockout cell line (HCT 116) | Human | TMTC2 | 1:2~1:4 | Negative | Online Inquiry |
KO13146 | TMTC2 Knockout cell line (HEK293) | Human | TMTC2 | 1:3~1:6 | Negative | Online Inquiry |
KO13147 | TMTC2 Knockout cell line (A549) | Human | TMTC2 | 1:3~1:4 | Negative | Online Inquiry |
TMTC2 Gene Knockout Cell Lines are innovative biological products designed to facilitate advanced genetic research by enabling precise studies on the TMTC2 gene's function and its implications in various biological processes. These knockout cell lines are derived through sophisticated CRISPR/Cas9 gene-editing technology, effectively disrupting the TMTC2 gene expression, allowing researchers to investigate the gene's role in cellular mechanisms without interference from the endogenous gene product.
At the molecular level, the knockout of the TMTC2 gene results in significant alterations in cell signaling pathways, impacting protein folding, quality control, and cellular stress responses. By utilizing these cell lines, scientists can conduct in-depth analyses identifying how the loss of TMTC2 activity influences cellular behavior, contributes to disease pathology, or affects treatment responses in various conditions, including neurodegenerative diseases and cancer.
The scientific importance of TMTC2 Gene Knockout Cell Lines extends beyond basic research; they are invaluable tools in translational research, aiding in drug discovery and therapeutic development. Researchers can model disease-specific mutations and evaluate novel therapeutics' efficacy in correcting or compensating for the loss of TMTC2 function, providing a comprehensive platform for preclinical studies.
Compared to traditional methods of gene knockout, such as homologous recombination, TMTC2 Gene Knockout Cell Lines offer superior speed, efficiency, and reproducibility. They provide consistency across experiments, reducing variability associated with clonal selection and gene targeting.
The value of these cell lines to researchers and clinicians lies in their reliability and ability to yield significant insights into therapeutic targets and disease mechanisms. With their ease of use, these models accelerate the pace of discovery and innovation in the life sciences field.
Our company is committed to advancing scientific research by providing high-quality biological products backed by our expertise in gene editing and cell line development. We assure researchers and clinicians of our rigorous quality control protocols and the scientific rigor behind our offerings, making TMTC2 Gene Knockout Cell Lines a trusted choice for groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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