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TMEM9B Knockout Cell Lines

Gene: TMEM9B

Official Full Name: TMEM9 domain family member Bprovided by HGNC

Gene Summary: Involved in positive regulation of canonical NF-kappaB signal transduction. Located in early endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20107 TMEM9B Knockout cell line (HeLa) Human TMEM9B 1:3~1:6 Negative Online Inquiry
KO20108 TMEM9B Knockout cell line (HCT 116) Human TMEM9B 1:2~1:4 Negative Online Inquiry
KO20109 TMEM9B Knockout cell line (HEK293) Human TMEM9B 1:3~1:6 Negative Online Inquiry
KO20110 TMEM9B Knockout cell line (A549) Human TMEM9B 1:3~1:4 Negative Online Inquiry

Background

TMEM9B Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of the TMEM9B gene, known for its role in the regulation of cell stress responses and membrane trafficking. This product enables researchers to create a robust environment for dissecting the biological functions of TMEM9B, particularly how it influences cellular pathways related to autophagy, immune response, and tumorigenesis.

The key mechanism behind the TMEM9B gene knockout involves CRISPR/Cas9 technology, which effectively disrupts the TMEM9B gene, allowing for the observation of phenotypic changes that result from its absence. This knockout model serves as a critical tool in elucidating the gene's contributions to normal cellular functions and disease states, providing insights into potential therapeutic targets and biomarkers.

The scientific importance of TMEM9B Gene Knockout Cell Lines extends into various research domains, including cancer biology, neurobiology, and immunology. In clinical settings, understanding the role of TMEM9B can pave the way for innovative treatment strategies, particularly in diseases where autophagy is dysregulated. Researchers can leverage these cell lines to identify new compounds that may restore normal functions in disease pathology or to screen for genetic interactions.

What sets TMEM9B Gene Knockout Cell Lines apart from conventional cell models is their specificity and the thorough validation of the knockout efficacy, ensuring reliable and reproducible results. The product's unique advantage lies in its ability to mimic physiological conditions more closely than alternative approaches, such as transient silencing or overexpression, thereby enhancing translational relevance.

For researchers and clinicians exploring the complex roles of membrane trafficking and stress response mechanisms in health and disease, TMEM9B Gene Knockout Cell Lines offer invaluable insights. Our commitment to quality and scientific integrity ensures that you receive high-fidelity tools, backed by a team of experts in molecular biology and gene editing. Trust in our products, designed to empower your research and advance our understanding of biology at the molecular level.

Please note that all services are for research use only. Not intended for any clinical use.

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