Gene: TMEM14A
Official Full Name: transmembrane protein 14Aprovided by HGNC
Gene Summary: Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27268 | TMEM14A Knockout cell line (HeLa) | Human | TMEM14A | 1:3~1:6 | Negative | Online Inquiry |
KO27269 | TMEM14A Knockout cell line (HCT 116) | Human | TMEM14A | 1:2~1:4 | Negative | Online Inquiry |
KO27270 | TMEM14A Knockout cell line (HEK293) | Human | TMEM14A | 1:3~1:6 | Negative | Online Inquiry |
KO27271 | TMEM14A Knockout cell line (A549) | Human | TMEM14A | 1:3~1:4 | Negative | Online Inquiry |
TMEM14A Gene Knockout Cell Lines are an advanced biotechnological tool designed to facilitate the study of the TMEM14A gene's role in cellular functions and disease mechanisms. These specifically engineered cell lines have undergone targeted gene editing to disrupt the expression of the TMEM14A gene, enabling researchers to investigate the gene's contributions to processes such as lipid metabolism, mitochondrial function, and cellular responses to stress.
The key functions of the TMEM14A Gene Knockout Cell Lines arise from their ability to model the absence of TMEM14A protein, which is crucial for understanding its involvement in various biological pathways. By utilizing techniques such as CRISPR-Cas9 gene editing, these knockout lines provide precise control over genetic variables, allowing researchers to examine the downstream effects of gene loss on cell physiology, signaling pathways, and cell viability.
From a scientific perspective, these knockout cell lines are invaluable in both research and clinical settings. They serve as an experimental platform for drug discovery, particularly in identifying compounds that may restore normal function in cells deficient in TMEM14A. Additionally, they are instrumental in elucidating the pathophysiological mechanisms underlying diseases linked to lipid dysregulation and mitochondrial dysfunction, which could lead to novel therapeutic interventions.
Compared to traditional cell line models, TMEM14A Gene Knockout Cell Lines offer several advantages. The precise gene inactivation allows for more accurate modeling of pathophysiological conditions, thereby improving the reproducibility and reliability of experimental results. Furthermore, they can save researchers time and resources by eliminating the need for extensive genetic manipulation after initial experimentation.
For researchers, clinicians, and pharmaceutical developers, the value of TMEM14A Gene Knockout Cell Lines lies in their ability to accelerate the understanding of complex biological systems and contribute to the development of targeted therapies. As a leader in genetic modification technologies, our company is dedicated to providing high-quality, reliable biological products that empower scientific exploration and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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