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TMBIM1 Knockout Cell Lines

Gene: TMBIM1

Official Full Name: transmembrane BAX inhibitor motif containing 1provided by HGNC

Gene Summary: Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi membrane; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13365 TMBIM1 Knockout cell line (HeLa) Human TMBIM1 1:3~1:6 Negative Online Inquiry
KO13366 TMBIM1 Knockout cell line (HCT 116) Human TMBIM1 1:2~1:4 Negative Online Inquiry
KO13367 TMBIM1 Knockout cell line (HEK293) Human TMBIM1 1:3~1:6 Negative Online Inquiry
KO13368 TMBIM1 Knockout cell line (A549) Human TMBIM1 1:3~1:4 Negative Online Inquiry

Background

TMBIM1 Gene Knockout Cell Lines represent a significant advancement in genetic research, providing valuable tools for investigating the functional roles of the TMBIM1 gene in various biological processes. TMBIM1, or Transmembrane BAX Inhibitor Motif Containing 1, is implicated in cellular stress responses, apoptosis regulation, and cancer biology. The knockout of this gene allows researchers to delineate the pathways and mechanisms mediated by TMBIM1, thereby illuminating its contributions to homeostasis and disease phenotypes.

These cell lines are developed using CRISPR-Cas9 gene editing technology, offering a precise and efficient method for generating specific gene knockouts. By selectively disrupting the TMBIM1 gene, researchers can observe the resultant phenotypic changes and cellular behaviors, enabling them to uncover the gene's function in apoptosis, cell survival, and response to stressors. The ability to study TMBIM1-deficient cells provides insights not only into basic biology but also into the potential therapeutic targets for conditions associated with dysregulated apoptosis, including cancer.

The scientific importance of TMBIM1 Gene Knockout Cell Lines extends to their applications in drug discovery, where they serve as a critical resource for screening anti-cancer compounds or validating therapeutic targets. Moreover, the knockout cell lines facilitate detailed studies of intracellular signaling pathways, contributing to a greater understanding of tumorigenesis and therapeutic resistance mechanisms.

A distinguishing advantage of TMBIM1 Gene Knockout Cell Lines is their specificity and adaptability. Unlike traditional knockdown methods, which may produce variable results due to residual gene expression, CRISPR-mediated knockout leads to complete gene ablation, resulting in more reliable and reproducible outcomes. Additionally, these cell lines can be tailored to meet the needs of various experimental setups, enhancing their versatility for diverse research applications.

Researchers and clinicians stand to benefit significantly from using TMBIM1 Gene Knockout Cell Lines in their work. By providing precise models for investigating the molecular underpinnings of critical biological processes, these cell lines enable scientists to generate robust data that can inform future therapeutic strategies.

At our company, we specialize in developing high-quality genetic tools for life science research, ensuring that our products are backed by extensive expertise and commitment to scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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