Gene: TFAP4
Official Full Name: transcription factor AP-4provided by HGNC
Gene Summary: Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13446 | TFAP4 Knockout cell line (HeLa) | Human | TFAP4 | 1:3~1:6 | Negative | Online Inquiry |
KO13447 | TFAP4 Knockout cell line (HCT 116) | Human | TFAP4 | 1:2~1:4 | Negative | Online Inquiry |
KO13448 | TFAP4 Knockout cell line (HEK293) | Human | TFAP4 | 1:3~1:6 | Negative | Online Inquiry |
KO13449 | TFAP4 Knockout cell line (A549) | Human | TFAP4 | 1:3~1:4 | Negative | Online Inquiry |
TFAP4 Gene Knockout Cell Lines are genetically engineered cell lines in which the TFAP4 gene has been inactivated or disrupted, allowing researchers to study the specific functions and biological implications of this transcription factor. TFAP4, or Transcription Factor Activator Protein 4, plays a crucial role in regulating gene expression involved in cellular processes such as proliferation, differentiation, and response to stress. By using these knockout cell lines, scientists can investigate the downstream effects of TFAP4 in a controlled laboratory setting, elucidating its contributions to various physiological and pathological conditions.
The unique mechanism of action behind these knockout cell lines involves precise gene-editing technologies, such as CRISPR/Cas9, which ensure a specific and irreversible mutation of the TFAP4 gene. This disruption allows for comprehensive functional assays to evaluate changes in cellular behavior, signal transduction pathways, and gene expression profiles. The insights gained from these studies have significant implications in fields such as developmental biology, cancer research, and regenerative medicine, where understanding the role of specific transcription factors can guide therapeutic strategies.
Compared to conventional cell lines that express the TFAP4 gene, TFAP4 Gene Knockout Cell Lines provide an invaluable tool for researchers by eliminating confounding variables associated with gene expression variability. This specificity allows for a more accurate interpretation of experimental results, making it easier to establish causal relationships. Furthermore, these cell lines are compatible with high-throughput screening assays, expediting the drug discovery process and enhancing the efficiency of experimental designs.
The value of TFAP4 Gene Knockout Cell Lines extends beyond mere research applications; they can also inform clinical practices by identifying potential biomarkers or therapeutic targets for conditions associated with aberrant TFAP4 activity. Their development generates a framework for translational research, ensuring that compelling laboratory findings can be effectively harnessed for clinical interventions.
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Please note that all services are for research use only. Not intended for any clinical use.
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