Gene: TCF3
Official Full Name: transcription factor 3provided by HGNC
Gene Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35107 | TCF3 Knockout cell line (HeLa) | Human | TCF3 | 1:3~1:6 | Negative | Online Inquiry |
KO35108 | TCF3 Knockout cell line (HCT 116) | Human | TCF3 | 1:2~1:4 | Negative | Online Inquiry |
KO35109 | TCF3 Knockout cell line (HEK293) | Human | TCF3 | 1:3~1:6 | Negative | Online Inquiry |
KO35110 | TCF3 Knockout cell line (A549) | Human | TCF3 | 1:3~1:4 | Negative | Online Inquiry |
TCF3 Gene Knockout Cell Lines are precision-engineered cellular models designed specifically to facilitate the in-depth study of the TCF3 gene and its associated pathways. These cell lines have been meticulously developed using CRISPR-Cas9 gene editing technology, which has revolutionized genetic research by allowing scientists to create targeted gene knockouts with a high degree of specificity. By knocking out the TCF3 gene, researchers can assess its role in essential biological processes, including cellular differentiation, proliferation, and response to various stimuli.
The primary function of TCF3 knockout cell lines is to provide insights into the signaling pathways regulated by TCF3, particularly in contexts such as stem cell biology, immune system development, and oncogenesis. By studying these cell lines, researchers can elucidate TCF3’s contributions to both normal physiological functions and pathological states, thereby enhancing our understanding of diseases such as leukemia and other malignancies where TCF3 is implicated.
In research and clinical settings, these knockout cell lines offer significant advantages over traditional methods of study, such as animal models or less precise RNA interference approaches. One key advantage is the ability to consistently generate homozygous knockout lines, enabling more reliable data collection and reproducibility in experiments. Moreover, they allow for rapid screening of therapeutic candidates, as researchers can assess compounds in a true TCF3-deficient background without the variability associated with less controlled systems.
The unique selling points of TCF3 Gene Knockout Cell Lines lie in their unparalleled accuracy and ease of use. They are ready-to-use, saving researchers valuable time in the setup and implementation phases of experimental design. Additionally, the insights gained from utilizing these cell lines can directly inform how TCF3-targeting therapies might be developed, making them invaluable to both academic and pharmaceutical research sectors.
In conclusion, TCF3 Gene Knockout Cell Lines represent a powerful tool for advancing genetic research, and their precise development highlights our commitment to providing high-quality biological products. Our company specializes in producing cutting-edge research tools that empower scientists to push the frontiers of knowledge within the life sciences, ultimately aiding in the development of innovative therapies and interventions.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.