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TBCK Knockout Cell Lines

Gene: TBCK

Official Full Name: TBC1 domain containing kinaseprovided by HGNC

Gene Summary: This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22149 TBCK Knockout cell line (HeLa) Human TBCK 1:3~1:6 Negative Online Inquiry
KO22150 TBCK Knockout cell line (HCT 116) Human TBCK 1:2~1:4 Negative Online Inquiry
KO22151 TBCK Knockout cell line (HEK293) Human TBCK 1:3~1:6 Negative Online Inquiry
KO22152 TBCK Knockout cell line (A549) Human TBCK 1:3~1:4 Negative Online Inquiry

Background

TBCK Gene Knockout Cell Lines are specialized cellular models engineered to lack the TBCK (TBC1 domain containing kinase) gene, a critical player in cellular signaling pathways and metabolic regulation. These knockout cell lines serve as powerful tools for researchers exploring the biological functions of TBCK, particularly in relation to mTOR signaling pathways, cell growth, and differentiation processes. By creating a controlled environment where the TBCK gene is selectively disabled, these cell lines allow for precise investigations into the downstream effects of TBCK deficiency, facilitating a deeper understanding of its role in various cellular contexts.

The mechanism behind TBCK gene knockout involves the use of CRISPR/Cas9 technology, which enables targeted genomic modifications with high specificity. This methodology not only ensures that the TBCK gene is effectively disrupted but also allows for the potential exploration of compensatory biological pathways that may be activated in its absence. The unique functionality of these cell lines is crucial in both academic research and clinical settings, particularly in the field of cancer biology, metabolic disorders, and genetic diseases where TBCK's role may be implicated.

One of the significant advantages of using TBCK Gene Knockout Cell Lines is their ability to provide clarity on the functional consequences of gene deletion, surpassing traditional methods that may rely on pharmacological inhibition or overexpression models. Unlike these alternatives, the knockout strategy minimizes off-target effects and provides a more accurate representation of physiological conditions. This precise genetic engineering makes the cell lines invaluable for drug discovery, biomarker identification, and understanding the molecular mechanisms underpinning diseases linked to TBCK.

Researchers, clinicians, and pharmaceutical companies will find TBCK Gene Knockout Cell Lines to be a valuable asset for their studies due to their robustness and versatility. These knockout models pave the way for groundbreaking discoveries and therapies that can lead to significant advancements in patient care and treatment protocols.

Our company specializes in the production of high-quality genetic models, leveraging cutting-edge technology and extensive expertise in gene editing. We are committed to providing researchers and clinicians with the tools they need to accelerate their scientific endeavors and transform health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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