Gene: TBC1D20
Official Full Name: TBC1 domain family member 20provided by HGNC
Gene Summary: This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04541 | TBC1D20 Knockout cell line (HeLa) | Human | TBC1D20 | 1:3~1:6 | Negative | Online Inquiry |
KO04542 | TBC1D20 Knockout cell line (HCT 116) | Human | TBC1D20 | 1:2~1:4 | Negative | Online Inquiry |
KO04543 | TBC1D20 Knockout cell line (HEK293) | Human | TBC1D20 | 1:3~1:6 | Negative | Online Inquiry |
KO04544 | TBC1D20 Knockout cell line (A549) | Human | TBC1D20 | 1:3~1:4 | Negative | Online Inquiry |
TBC1D20 Gene Knockout Cell Lines are specialized cellular models generated by targeted gene editing techniques to disrupt the TBC1D20 gene, which encodes a protein implicated in various cellular processes including endocytic recycling and insulin signaling. These knockout cell lines provide a powerful platform for studying the cellular and molecular consequences of the loss of TBC1D20 function, enabling researchers to investigate the gene’s role in metabolism, disease pathogenesis, and cellular communication pathways.
The key function of TBC1D20 lies in its GTPase-activating protein (GAP) activity, which regulates RAB GTPases involved in intracellular transport. By knocking out the TBC1D20 gene, these cell lines facilitate the exploration of altered protein interactions and pathways that occur when normal cellular signaling is disrupted. This makes them invaluable not only for basic biological research but also for translational studies involving metabolic disorders and cancer.
The scientific importance of TBC1D20 Gene Knockout Cell Lines extends into both research and clinical applications. They serve as essential tools for drug discovery, enabling the identification of novel therapeutic targets and the testing of new compounds in systems that closely mimic disease conditions. Additionally, these lines can aid in biomarker discovery and validation, thereby enhancing understanding of disease mechanisms.
What sets our TBC1D20 Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability. We employ advanced CRISPR-Cas9 technology to ensure efficient and precise gene editing, resulting in consistent knockout phenotypes across multiple batches. Furthermore, our cell lines come with comprehensive documentation of characterization, making them ready-to-use for immediate application in various experimental setups.
For researchers and clinicians focused on gene function studies, metabolic disease research, and therapeutic development, TBC1D20 Gene Knockout Cell Lines present an unparalleled resource. They offer the potential for groundbreaking insights and innovation in the fields of molecular biology and medicine.
Our company boasts extensive experience in producing high-quality biological products, grounded in robust scientific innovation and precision. We are committed to advancing research capabilities and optimizing experimental outcomes for the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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