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TAX1BP3 Knockout Cell Lines

Gene: TAX1BP3

Official Full Name: Tax1 binding protein 3provided by HGNC

Gene Summary: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26726 TAX1BP3 Knockout cell line (HeLa) Human TAX1BP3 1:3~1:6 Negative Online Inquiry
KO26727 TAX1BP3 Knockout cell line (HCT 116) Human TAX1BP3 1:2~1:4 Negative Online Inquiry
KO26728 TAX1BP3 Knockout cell line (HEK293) Human TAX1BP3 1:3~1:6 Negative Online Inquiry
KO26729 TAX1BP3 Knockout cell line (A549) Human TAX1BP3 1:3~1:4 Negative Online Inquiry

Background

TAX1BP3 Gene Knockout Cell Lines are specifically engineered cellular models utilized for the investigation of the TAX1BP3 gene's role in various biological processes and disease states. TAX1BP3 (Tax1-binding protein 3) is implicated in diverse cellular functions, including apoptosis, immune response modulation, and signaling pathways associated with cancer. These knockout cell lines allow researchers to systematically study the consequences of TAX1BP3 gene absence, providing invaluable insights into its functionality and potential as a therapeutic target.

The primary mechanism of these knockout cell lines is the complete disruption of the TAX1BP3 gene, achieved through advanced CRISPR-Cas9 gene editing technology. This precise genetic alteration enables the examination of phenotypic changes, cellular behavior, and pathways that are otherwise obscured in wild-type cells. By comparing the knockout cellular responses to those of their wild-type counterparts, scientists are equipped to elucidate the gene's specific roles and contributions to various diseases, enhancing our understanding of its mechanisms in health and pathology.

The scientific significance of TAX1BP3 Gene Knockout Cell Lines extends across research and clinical applications, offering essential tools for cancer research, autoimmune studies, and therapeutic development. These models provide a controlled environment to assess drug responses and validate new therapeutic strategies aimed at targeting relevant pathways influenced by TAX1BP3.

One of the key advantages of utilizing TAX1BP3 knockout cell lines is their ability to generate consistent, reproducible results that facilitate high-throughput screening and compound efficacy testing. Compared to conventional cell lines that may harbor multiple genetic variations, these knockouts offer specificity and clarity, ultimately streamlining the research process and reducing the ambiguity seen with other models.

For researchers and clinicians focused on unraveling the complexities of cellular mechanisms or identifying new therapeutic approaches, TAX1BP3 Gene Knockout Cell Lines represent a critical asset. By providing unparalleled insights into gene function, these models empower the scientific community to pursue innovative solutions in disease treatment.

Our company specializes in offering high-quality biological products, underpinned by robust research methodologies and a commitment to advancing scientific discovery. With an expertise in gene editing technologies and cell line development, we are dedicated to providing researchers with the tools necessary to explore and understand the intricacies of gene functionality and its implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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