Gene: TARBP1
Official Full Name: tRNA guanosine 2 -O-methyltransferase TARBP1provided by HGNC
Gene Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35134 | TARBP1 Knockout cell line (HeLa) | Human | TARBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO35135 | TARBP1 Knockout cell line (HCT 116) | Human | TARBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO35136 | TARBP1 Knockout cell line (HEK293) | Human | TARBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO35137 | TARBP1 Knockout cell line (A549) | Human | TARBP1 | 1:3~1:4 | Negative | Online Inquiry |
TARBP1 Gene Knockout Cell Lines are specialized cell models engineered to have the TARBP1 (TAR RNA-binding protein 1) gene disrupted, allowing researchers to study the biological implications of this key protein's absence. TARBP1 plays a pivotal role in the innate immune response and RNA regulation, particularly in the context of viral infections and cellular stress. By utilizing these knockout cell lines, scientists can investigate the effects on viral replication, gene expression, and the modulation of signaling pathways, thereby providing insights into the mechanisms governing cellular responses to pathogens.
The primary function of these cell lines is to elucidate the role of TARBP1 in processes such as RNA silencing and modulation of interferon responses. When the TARBP1 gene is knocked out, researchers can observe phenotypic changes and altered cellular behaviors, such as enhanced susceptibility to viral infections or dysregulated immune responses, thereby advancing understanding in virology and immunology.
In research and clinical settings, TARBP1 Gene Knockout Cell Lines hold significant scientific importance as they serve as robust tools for drug discovery and testing therapeutic interventions targeting viral infections. Their applications extend to studying autoimmune diseases, cancers where viral components play a role, or any conditions where RNA modulation is crucial.
Compared to alternative models, the unique selling point of these knockout cell lines lies in their specificity; they offer a more precise platform for investigating the outcomes of TARBP1 disruption without confounding influences from residual gene expression. This targeted approach enhances the reproducibility and reliability of experimental results, yielding valuable data for downstream applications.
Given the increasing demand for accurate and reliable research models in the field of molecular biology, the TARBP1 Gene Knockout Cell Lines represent an indispensable tool. Researchers and clinicians can leverage the insights gained from these models to develop innovative therapies that capitalize on the biological roles of TARBP1. Our company specializes in providing high-quality biological products with robust technical support, ensuring that our customers are equipped with the best resources to propel their research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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