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TAGLN2 Knockout Cell Lines

Gene: TAGLN2

Official Full Name: transgelin 2provided by HGNC

Gene Summary: The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06449 TAGLN2 Knockout cell line (HeLa) Human TAGLN2 1:3~1:6 Negative Online Inquiry
KO06450 TAGLN2 Knockout cell line (HCT 116) Human TAGLN2 1:2~1:4 Negative Online Inquiry
KO06451 TAGLN2 Knockout cell line (HEK293) Human TAGLN2 1:3~1:6 Negative Online Inquiry
KO06452 TAGLN2 Knockout cell line (A549) Human TAGLN2 1:3~1:4 Negative Online Inquiry

Background

TAGLN2 Gene Knockout Cell Lines are specialized cellular models in which the TAGLN2 gene has been intentionally disrupted. This genetic modification facilitates an in-depth study of the TAGLN2 protein's role in cellular processes, allowing researchers to investigate its contributions to various physiological and pathological conditions. By effectively 'knocking out' this gene, scientists can better understand the underlying mechanisms of gene function and regulation within a controlled laboratory environment.

The primary mechanism through which these knockout cell lines operate lies in the absence of the TAGLN2 protein, which is known for its involvement in smooth muscle contraction, cell motility, and cytoskeletal dynamics. By studying cells devoid of TAGLN2, researchers can elucidate how its absence affects cellular signaling pathways, gene expression profiles, and interaction with other cytoskeletal elements. This makes the cell lines a powerful tool for research into diseases such as cardiovascular disorders and cancer, wherein TAGLN2 may play a critical role.

The scientific importance of TAGLN2 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical settings. These models can be utilized to test therapeutic strategies, identify potential drug targets, and further understand disease mechanisms. Their use also extends to drug discovery, where researchers can evaluate the efficacy of novel compounds on cells with altered TAGLN2 expression.

Compared to alternative cell lines, TAGLN2 knockout models offer unique advantages such as high specificity in gene editing and reproducibility in research outputs. Unlike transient transfection methods, which can yield inconsistent results due to variable expression levels, these knockout lines provide a stable genetic backdrop, ensuring reliable and consistent experimental conditions that can enhance the reproducibility and validity of findings.

Researchers and clinicians alike will find these cell lines invaluable due to their ability to model specific diseases more accurately and facilitate a deeper understanding of TAGLN2's biological functions. The precise genetic modification enables experiments that can lead to breakthroughs in personalized medicine, ultimately improving therapeutic outcomes.

Our company prides itself on its cutting-edge expertise in providing high-quality genetic tools for researchers, reflecting our commitment to advancing scientific discovery in the field of molecular biology and beyond. By leveraging our rigorous scientific standards and innovative methodologies, we aim to empower researchers to uncover new insights into gene function and regulation through the use of our TAGLN2 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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