Gene: SURF4
Official Full Name: surfeit 4provided by HGNC
Gene Summary: This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03830 | SURF4 Knockout cell line (HeLa) | Human | SURF4 | 1:3~1:6 | Negative | Online Inquiry |
KO03831 | SURF4 Knockout cell line (HCT 116) | Human | SURF4 | 1:2~1:4 | Negative | Online Inquiry |
KO03832 | SURF4 Knockout cell line (HEK293) | Human | SURF4 | 1:3~1:6 | Negative | Online Inquiry |
KO03833 | SURF4 Knockout cell line (A549) | Human | SURF4 | 1:3~1:4 | Negative | Online Inquiry |
SURF4 Gene Knockout Cell Lines are specialized cellular models created through gene editing techniques to specifically disrupt the expression of the SURF4 gene, which encodes a protein implicated in the transport and processing of secretory proteins within the endoplasmic reticulum. These cell lines are invaluable tools for researchers aiming to elucidate the functional roles of SURF4 in cellular processes such as protein sorting, secretion, and potentially in disease mechanisms associated with protein misfolding.
The key function of the SURF4 Gene Knockout Cell Lines lies in their ability to facilitate the study of protein trafficking pathways and the biological implications of SURF4 absence. The knockout of this gene disrupts normal protein dynamics, allowing researchers to observe resultant changes in cellular homeostasis, stress responses, and overall cellular physiology in a controlled environment. Furthermore, these cell lines are designed to be amenable for high-throughput screening methods, enhancing the efficiency of experimental workflows.
From a scientific perspective, these knockout cell lines are fundamental for advancing our understanding of diseases linked to protein mismanagement, including neurodegenerative disorders and secretory pathway diseases. They open avenues for testing therapeutic strategies, validating drug targets, and understanding the fundamental biology of cellular systems.
What sets our SURF4 Gene Knockout Cell Lines apart from alternative models is our rigorous quality control and validation process, ensuring that the gene deletion is complete and functions as intended. Additionally, our cell lines are available with specific background strains, offering customization to fit diverse experimental setups without the variability that can stem from using less-characterized lines.
For researchers and clinicians, the value of SURF4 Gene Knockout Cell Lines lies not just in their ability to provide insights into the fundamental role of SURF4 but also in their potential applications for drug discovery and development of therapeutic interventions. With our company’s extensive expertise in genetic engineering and commitment to supporting cutting-edge research, we provide researchers with reliable tools that drive scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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