Gene: SUN3
Official Full Name: Sad1 and UNC84 domain containing 3provided by HGNC
Gene Summary: Predicted to enable protein-membrane adaptor activity. Predicted to be located in nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21019 | SUN3 Knockout cell line (HCT 116) | Human | SUN3 | 1:2~1:4 | Negative | Online Inquiry |
SUN3 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene editing to create a specific knockout of the SUN3 gene, a critical component involved in nuclear positioning, cell migration, and muscle integrity. By employing the CRISPR-Cas9 genome editing technology, these cell lines allow researchers to study the functional consequences of SUN3 deletion, providing essential insights into cellular mechanisms foundational to both normal physiology and disease pathologies.
The SUN3 gene knockout operates through the disruption of the genomic sequence of SUN3, leading to a loss of gene product expression. This alteration significantly affects various cellular processes, including cytoskeletal organization and cellular signaling pathways. As a result, researchers can leverage these cell lines to explore the implications of SUN3 loss in areas such as muscular dystrophy, cancer progression, and developmental biology.
From a scientific perspective, SUN3 Gene Knockout Cell Lines are invaluable in both fundamental and applied research. They are particularly useful in elucidating the roles of nuclear envelope integrity in cellular function, making them a pivotal tool for understanding disease mechanisms. Their applications extend to drug development and discovering potential therapeutic targets, emphasizing their utility in clinical research environments.
What sets SUN3 Gene Knockout Cell Lines apart from conventional tools is their precision and reliability. Unlike RNA interference methods, which can result in off-target effects, the CRISPR-Cas9 paradigm offers a definitive and stable gene disruption, empowering researchers with the ability to repeat experiments and obtain consistent data. Additionally, these cell lines come with comprehensive documentation and user-friendly protocols, facilitating seamless integration into existing research workflows.
Organizations and researchers in molecular biology, gene therapy, and oncology will find immense value in utilizing SUN3 Gene Knockout Cell Lines. Their clear delineation of gene function fosters innovation, facilitating the advancement of therapeutic strategies and enhancing our understanding of critical biological processes. Our company has a long-standing commitment to delivering high-quality biological products, backed by extensive validation, to propel your research endeavors forward.
Please note that all services are for research use only. Not intended for any clinical use.
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