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SULT2B1 Knockout Cell Lines

Gene: SULT2B1

Official Full Name: sulfotransferase family 2B member 1provided by HGNC

Gene Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20223 SULT2B1 Knockout cell line (HCT 116) Human SULT2B1 1:2~1:4 Negative Online Inquiry
KO20224 SULT2B1 Knockout cell line (A549) Human SULT2B1 1:3~1:4 Negative Online Inquiry

Background

SULT2B1 Gene Knockout Cell Lines are specialized mammalian cell lines engineered to lack the functional expression of the SULT2B1 gene, which encodes sulfotransferase enzymes crucial for the metabolism of various hormones, neurotransmitters, and drugs. This targeted knockout allows researchers to study the physiological and pathological roles of SULT2B1 with precision and clarity.

The primary function of SULT2B1 is to facilitate the sulfation process, a key biochemical modification that regulates the activity and bioavailability of numerous biologically active compounds. By utilizing these knockout cell lines, scientists can investigate how the absence of SULT2B1 affects cellular signaling pathways, gene expression, and metabolic responses to various stimuli, providing insights into disease mechanisms and therapeutic targets.

Scientifically, SULT2B1 Gene Knockout Cell Lines hold significant importance in both research and clinical settings. They enable researchers to dissect the role of SULT2B1 in conditions such as hormonal disorders, cancers, and drug interactions, offering a powerful platform for drug development and safety testing. By understanding B1's role in these processes, the data derived from these cell lines can help guide the design of more effective therapies with minimized side effects.

Compared to conventional wild-type cell lines, SULT2B1 knockout models provide a streamlined approach for clear and reproducible results. These cell lines minimize the confounding effects of SULT2B1 expression in experimental outcomes, allowing for a focused investigation of specific signaling pathways or biochemical processes.

For researchers and clinicians dedicated to advancing the understanding of sulfation and its implications in health and disease, SULT2B1 Gene Knockout Cell Lines represent a vital tool. They not only enhance the reliability of experimental data but also have the potential to aid in the discovery and development of novel therapeutic strategies.

Our company has extensive expertise in producing high-quality biological products, and we are committed to supporting the scientific community with innovative tools like SULT2B1 Gene Knockout Cell Lines that contribute to transformative research and breakthroughs in medical science.

Please note that all services are for research use only. Not intended for any clinical use.

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