Gene: SULF2
Official Full Name: sulfatase 2provided by HGNC
Gene Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13647 | SULF2 Knockout cell line (HeLa) | Human | SULF2 | 1:3~1:6 | Negative | Online Inquiry |
KO13648 | SULF2 Knockout cell line (HCT 116) | Human | SULF2 | 1:2~1:4 | Negative | Online Inquiry |
KO13649 | SULF2 Knockout cell line (HEK293) | Human | SULF2 | 1:3~1:6 | Negative | Online Inquiry |
KO13650 | SULF2 Knockout cell line (A549) | Human | SULF2 | 1:3~1:4 | Negative | Online Inquiry |
SULF2 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the function of the SULF2 gene, which encodes a sulfatase involved in the modulation of heparan sulfate proteoglycans. These cell lines serve as invaluable tools for understanding the role of SULF2 in cellular pathways, particularly in cancer biology, where altered glycosylation patterns can affect tumor progression and metastasis.
The primary mechanism of action of these knockout cell lines involves the loss of SULF2's enzymatic activity that normally regulates the accessibility of growth factors and receptors, thereby influencing signal transduction pathways such as the Wnt and FGF pathways. By utilizing these knockout lines, researchers can elucidate the physiological and pathological roles of SULF2, providing insights into the molecular underpinnings of various diseases, including cancer and developmental disorders.
The scientific importance of SULF2 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they facilitate the study of gene function, enabling scientists to explore potential therapeutic targets, while in a clinical context, these cell lines can aid in the development of novel treatment strategies aimed at manipulating SULF2 activity to confer therapeutic benefits.
Unique selling points of our SULF2 Gene Knockout Cell Lines include their high specificity and reproducibility, which are essential for generating consistent and reliable data. Unlike other cell lines that may exhibit heterogeneous genetic backgrounds, our knockout models offer a fully characterized system that ensures the fidelity of experimental results, supporting robust conclusions about gene function.
By integrating these cell lines into your research endeavors, you will have the capability to uncover novel biological insights that could drive advancements in cancer therapy and regenerative medicine. Our company specializes in developing high-quality gene editing tools and cell lines, underpinned by extensive experience in molecular biology and genetics, ensuring you have access to reliable resources that meet your scientific needs.
Please note that all services are for research use only. Not intended for any clinical use.
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