Gene: STXBP1
Official Full Name: syntaxin binding protein 1provided by HGNC
Gene Summary: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35175 | STXBP1 Knockout cell line (HeLa) | Human | STXBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO35176 | STXBP1 Knockout cell line (HCT 116) | Human | STXBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO35177 | STXBP1 Knockout cell line (HEK293) | Human | STXBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO35178 | STXBP1 Knockout cell line (A549) | Human | STXBP1 | 1:3~1:4 | Negative | Online Inquiry |
STXBP1 Gene Knockout Cell Lines represent a pivotal tool in molecular biology, designed to facilitate the study of the STXBP1 gene, which is implicated in various neurological disorders, including intellectual disability and epilepsy. These cell lines are engineered to have a targeted disruption of the STXBP1 gene, thereby allowing researchers to observe the resulting phenotypic changes and elucidate the gene's biological functions and its role in disease mechanisms.
The primary function of STXBP1 Gene Knockout Cell Lines is to serve as a model system for investigating synaptic transmission and neurodevelopmental processes. By expressing a complete knockout of the STXBP1 gene, researchers can study the downstream effects of its absence on neuronal function as well as cellular signaling pathways associated with synaptic release. This can be critical for understanding how mutations in STXBP1 disrupt these processes, leading to pathological states.
In terms of scientific importance, these cell lines have broad applications in both research and clinical settings. They enable the exploration of therapeutic strategies and drug screening aimed at conditions associated with STXBP1 dysfunction. Furthermore, they provide insights into the biological underpinnings of synaptic disorders, essential for the development of future targeted treatments and interventions.
Compared to traditional wild-type cell lines, the STXBP1 Gene Knockout Cell Lines offer a more relevant and precise model for studying specific gene functions in pathophysiological contexts. Their ability to mimic aspects of human neurological diseases provides a distinct advantage over more generalized models and drives innovation in the field of cellular neuroscience.
For researchers and clinicians alike, the value of utilizing STXBP1 Gene Knockout Cell Lines lies in the ability to derive more conclusive and impactful data on the role of STXBP1 in neurological conditions, ultimately aiding in the development of next-generation therapeutic interventions. Our company specializes in providing high-quality biological research tools, and our expertise ensures that these knockout cell lines meet the rigorous standards required for cutting-edge research. By choosing our product, you are equipping your laboratory with a reliable and innovative resource to advance your studies in molecular genetics and neurobiology.
Please note that all services are for research use only. Not intended for any clinical use.
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