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STEAP3 Knockout Cell Lines

Gene: STEAP3

Official Full Name: STEAP3 metalloreductaseprovided by HGNC

Gene Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00400 STEAP3 Knockout cell line (HeLa) Human STEAP3 1:3~1:6 Negative Online Inquiry
KO13688 STEAP3 Knockout cell line (HCT 116) Human STEAP3 1:2~1:4 Negative Online Inquiry
KO13689 STEAP3 Knockout cell line (HEK293) Human STEAP3 1:3~1:6 Negative Online Inquiry
KO13690 STEAP3 Knockout cell line (A549) Human STEAP3 1:3~1:4 Negative Online Inquiry

Background

STEAP3 Gene Knockout Cell Lines are specialized genetically engineered cellular systems that have been developed to lack the STEAP3 gene, which encodes for a member of the six-transmembrane epithelial antigen of the prostate family. These cell lines serve as essential tools for investigating the biological functions of STEAP3, including its role in cancer biology, cellular iron homeostasis, and cell signaling pathways. By creating specific knockout models, researchers can study the phenotypic effects and molecular mechanisms that are altered in the absence of STEAP3, thus enhancing our understanding of its physiological and pathological roles.

The key functionality of STEAP3 Gene Knockout Cell Lines lies in their ability to facilitate precise gene function analyses. Utilizing CRISPR-Cas9 or similar gene-editing technologies, these knockout lines allow for the exploration of the impact of STEAP3's absence on various cellular processes, including proliferation, differentiation, and apoptosis. Researchers can utilize these models to assess the alterations in iron metabolism due to the loss of STEAP3, which has implications in diseases such as cancer, anemia, and other metabolic disorders.

In terms of scientific importance, these cell lines emerge as crucial resources for both basic and translational research. They aid in deciphering the complex roles of STEAP3 in tumor biology, potentially leading to novel therapeutic approaches in oncology. Moreover, understanding the mechanisms associated with STEAP3 can shine light on its potential as a biomarker for various diseases, thus driving the development of targeted treatments.

One key advantage of the STEAP3 Gene Knockout Cell Lines is their reliability and reproducibility, which are essential for experimental integrity. Compared to alternative models, these knockout cell lines provide a more focused approach, eliminating confounding variable influences that may arise from incomplete gene silencing methods. Furthermore, they come with the backing of robust characterization, ensuring that researchers can trust the data generated through these models.

Overall, STEAP3 Gene Knockout Cell Lines are invaluable for researchers and clinicians aiming to advance the field of molecular biology and therapeutic development. With our extensive expertise in genetic engineering and cell line development, we offer reliable and well-characterized cell lines that meet the demands of cutting-edge research and clinical applications. Our commitment to quality and scientific innovation ensures that you have the best tools available for your investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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