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STAU1 Knockout Cell Lines

Gene: STAU1

Official Full Name: staufen double-stranded RNA binding protein 1provided by HGNC

Gene Summary: Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13694 STAU1 Knockout cell line (HeLa) Human STAU1 1:3~1:6 Negative Online Inquiry
KO13695 STAU1 Knockout cell line (HCT 116) Human STAU1 1:2~1:4 Negative Online Inquiry
KO13696 STAU1 Knockout cell line (HEK293) Human STAU1 1:3~1:6 Negative Online Inquiry
KO13697 STAU1 Knockout cell line (A549) Human STAU1 1:3~1:4 Negative Online Inquiry

Background

STAU1 Gene Knockout Cell Lines are specialized cellular models engineered to specifically lack the expression of the Staufen 1 (STAU1) gene, which plays a crucial role in post-transcriptional regulation and cellular stress responses. These knockout cell lines facilitate the study of STAU1's function in mRNA localization, decay, and translational regulation, providing researchers with valuable tools to explore its impacts on various biological processes, including neuronal development and immune responses.

The key mechanism by which STAU1 influences cellular activities is through its ability to bind RNA molecules, guiding their stability and localization within the cytoplasm. By utilizing STAU1 knockout cell lines, researchers can elucidate the role of STAU1 in RNA metabolism and its implications in disease models, including neurodegenerative disorders and cancers. This specific gene knockout enhances the understanding of STAU1’s multi-faceted functions, allowing for targeted investigations into its effects on mRNA processing and cellular fate under stress conditions.

The scientific importance of these genetic models cannot be overstated. They serve as essential platforms for the screening of therapeutic targets and the validation of novel drugs aimed at diseases where STAU1 regulation is disrupted. Unlike traditional models that may express the STAU1 gene, these cell lines provide clear insight into the gene's loss-of-function effects, significantly enhancing experimental accuracy.

STAU1 Gene Knockout Cell Lines offer several advantages over alternative models, including precise gene editing with CRISPR technology, robust reproducibility in experimental outcomes, and readiness for high-throughput screening applications. For researchers and clinicians, this product enables a deeper understanding of complex cellular mechanisms, potentially leading to breakthroughs in gene regulation studies.

Our company, renowned for its commitment to cutting-edge biological tools and applications, leverages advanced genetic engineering techniques to deliver high-quality research products. By harnessing the versatility of STAU1 Gene Knockout Cell Lines, we empower scientists to explore new frontiers of gene function and regulation in health and disease contexts.

Please note that all services are for research use only. Not intended for any clinical use.

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