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STAG1 Knockout Cell Lines

Gene: STAG1

Official Full Name: STAG1 cohesin complex componentprovided by HGNC

Gene Summary: This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32035 STAG1 Knockout cell line (HeLa) Human STAG1 1:3~1:6 Negative Online Inquiry
KO32036 STAG1 Knockout cell line (HCT 116) Human STAG1 1:2~1:4 Negative Online Inquiry
KO32037 STAG1 Knockout cell line (HEK293) Human STAG1 1:3~1:6 Negative Online Inquiry
KO32038 STAG1 Knockout cell line (A549) Human STAG1 1:3~1:4 Negative Online Inquiry

Background

STAG1 Gene Knockout Cell Lines represent a groundbreaking innovation in molecular biology that facilitates the functional study of the STAG1 gene and its role in cellular processes. These cell lines are engineered to possess a targeted inactivation of the STAG1 gene, a crucial component of the cohesin complex that plays a significant role in chromosome segregation during cell division. By using CRISPR/Cas9 technology for gene editing, these knockout lines provide researchers with a robust tool to investigate the molecular pathways impacted by STAG1 disruption, thereby enabling insights into chromosomal abnormalities and their link to various cancers and developmental disorders.

At the heart of these knockout cell lines is the precise mechanism that allows for the deletion of the STAG1 gene, leading to a loss of function phenotype that can be rigorously studied in controlled laboratory settings. Researchers can utilize these cell lines in a variety of assays to elucidate the role of STAG1 in processes such as cell cycle regulation, DNA repair, and genomic stability. This understanding is imperative for both basic research and for the development of targeted therapies in clinical settings.

The scientific importance of STAG1 Gene Knockout Cell Lines cannot be understated; they serve as invaluable tools for advancing our understanding of genetic regulation and its implications for disease. Unlike traditional methods that may involve non-specific gene silencing or over-expression systems, these knockout lines provide a clear and unequivocal alteration of gene function, fostering reproducibility and reliability in experimental results.

For researchers and clinicians alike, the advantages offered by STAG1 Gene Knockout Cell Lines are substantial. These include high specificity, ease of use in various models, and the capability of yielding clear and interpretable data, making them superior to many alternatives available on the market. This empowers scientists to distinctly characterize the role of STAG1 in relevant biological contexts, which is essential for the progression of therapeutic discoveries.

In conclusion, the STAG1 Gene Knockout Cell Lines are a testament to our company's dedication to providing high-quality, innovative biological products that facilitate cutting-edge research. With expertise in gene editing technologies and a commitment to advancing the scientific community, we are proud to offer tools that enhance researchers' capabilities to explore the intricacies of gene function and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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