Gene: STAB2
Official Full Name: stabilin 2provided by HGNC
Gene Summary: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20714 | STAB2 Knockout cell line (HEK293) | Human | STAB2 | 1:3~1:6 | Negative | Online Inquiry |
STAB2 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate the study of the STAB2 gene's function in various biological processes. These cell lines are created using state-of-the-art CRISPR-Cas9 gene-editing technology, ensuring precise knockout of the STAB2 gene, which plays a crucial role in processes such as immune response, tissue homeostasis, and inflammation.
The key mechanism by which STAB2 Gene Knockout Cell Lines operate involves the disruption of the gene's coding sequence, thereby preventing the synthesis of the STAB2 protein. This targeted gene disruption allows researchers to investigate the downstream effects of STAB2 loss with high sensitivity and specificity, offering insights into cellular pathways and disease mechanisms associated with STAB2. By ensuring that the knockout is stable and heritable, these cell lines serve as a reliable platform for experiments ranging from basic cellular biology to the development of therapeutic strategies.
The scientific importance of these cell lines in research and clinical settings cannot be overstated. They are invaluable tools for studying the function of STAB2 in immune cell activation, the modulation of inflammatory responses, and their implications in various diseases, including cancer and autoimmune disorders. Moreover, they enable researchers to explore potential drug targets and biomarkers associated with STAB2, driving forward therapeutic innovations.
What sets STAB2 Gene Knockout Cell Lines apart from alternative products is their robust genetic validation and the comprehensive support provided by our team, which includes detailed protocols and assistance in experimental design. This reduces the time researchers typically spend validating new models and allows them to focus on deriving meaningful insights from their studies.
In conclusion, STAB2 Gene Knockout Cell Lines not only serve as critical tools for advancing scientific research but also provide a competitive edge for drug discovery and development. As a leader in biological research products, our commitment to quality and innovation ensures that researchers and clinicians have access to the best tools available, fostering impactful discoveries that can translate into clinical advances.
Please note that all services are for research use only. Not intended for any clinical use.
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