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SSR4 Knockout Cell Lines

Gene: SSR4

Official Full Name: signal sequence receptor subunit 4provided by HGNC

Gene Summary: This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13722 SSR4 Knockout cell line (HeLa) Human SSR4 1:3~1:6 Negative Online Inquiry
KO13723 SSR4 Knockout cell line (HCT 116) Human SSR4 1:2~1:4 Negative Online Inquiry
KO13724 SSR4 Knockout cell line (HEK293) Human SSR4 1:3~1:6 Negative Online Inquiry
KO13725 SSR4 Knockout cell line (A549) Human SSR4 1:3~1:4 Negative Online Inquiry

Background

SSR4 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disable the expression of the SSR4 gene, a crucial component involved in the protein secretion process within the endoplasmic reticulum. By utilizing CRISPR-Cas9 technology, these cell lines offer a streamlined model for investigating the intricate mechanisms of cellular function disrupted by SSR4 deficiency.

The key function of SSR4 is to assist in the proper folding and transport of proteins, particularly those destined for secretion. In the context of these knockout cell lines, researchers can observe changes in protein trafficking, evaluate compensatory cellular responses, and investigate the implications of altered glycosylation patterns. The mechanism underlying the knockout allows for precise examination of resultant phenotypic and molecular adaptations, making these cell lines a valuable resource for studying protein misfolding diseases, therapeutic protein production, and cellular stress responses.

From a scientific perspective, SSR4 Gene Knockout Cell Lines hold immense importance in both research and clinical applications. They can be utilized in drug discovery processes, particularly for screening compounds that modulate protein secretion pathways, as well as in understanding disease mechanisms such as those observed in certain cancers and metabolic disorders.

One of the key advantages of our SSR4 Gene Knockout Cell Lines is the depth of functional analysis they enable compared to traditional wild-type cell lines. The ability to specifically and reproducibly eliminate the SSR4 gene allows for greater clarity in experimental outcomes, facilitating more robust results in studies focused on protein dynamics and cellular response mechanisms.

For researchers and clinicians alike, the practical benefits of utilizing SSR4 Gene Knockout Cell Lines extend to the validation of novel treatment pathways, advancing our understanding of cellular processes with significant implications in therapeutic development.

Our company not only excels in providing high-quality genetic models but also prides itself on supporting the scientific community through expert guidance and comprehensive resources. This commitment ensures that our users gain maximum value from their research endeavors, fostering innovations that could lead to meaningful advancements in healthcare and biotechnology.

Please note that all services are for research use only. Not intended for any clinical use.

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