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SRSF4 Knockout Cell Lines

Gene: SRSF4

Official Full Name: serine and arginine rich splicing factor 4provided by HGNC

Gene Summary: Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35465 SRSF4 Knockout cell line (HeLa) Human SRSF4 1:3~1:6 Negative Online Inquiry
KO35466 SRSF4 Knockout cell line (HCT 116) Human SRSF4 1:2~1:4 Negative Online Inquiry
KO35467 SRSF4 Knockout cell line (HEK293) Human SRSF4 1:3~1:6 Negative Online Inquiry
KO35468 SRSF4 Knockout cell line (A549) Human SRSF4 1:3~1:4 Negative Online Inquiry

Background

SRSF4 Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of gene function and regulatory mechanisms involving the SRSF4 gene, which encodes a splicing factor implicated in pre-mRNA processing. These knockout models allow researchers to explore the functional consequences of SRSF4 gene ablation, particularly in contexts related to alternative splicing, gene expression regulation, and cellular responses to stress or environmental changes.

The key function of SRSF4 Gene Knockout Cell Lines lies in their ability to provide a clean background for the examination of the splicing pathways influenced by SRSF4. By utilizing CRISPR/Cas9 technology, these cell lines exhibit precise deletions of the SRSF4 gene, enabling scientists to observe resultant phenotypic changes, signaling pathways, and proliferative behavior in vitro. This approach provides an invaluable system for dissecting the role of SRSF4 in various cellular processes and understanding its potential implications in conditions such as cancer, neurodegeneration, and other diseases.

The scientific importance of these cell lines cannot be overstated, as they serve as critical tools in both academic research and clinical studies. They facilitate the identification of novel therapeutic targets and the characterization of disease mechanisms, thus contributing to the development of innovative strategies in drug discovery and personalized medicine.

What sets SRSF4 Gene Knockout Cell Lines apart from existing alternatives is their high specificity and reproducibility of knockout efficiency, as well as their compatibility with various cell types, making them versatile for diverse experimental designs. Additionally, these cell lines are validated through rigorous quality control processes, ensuring that researchers gain reliable data for their studies.

For researchers and clinicians, the value of SRSF4 Gene Knockout Cell Lines lies in their potential to unlock insights into complex biological pathways, ultimately advancing the understanding of gene regulation and its impact on human health. Our company, with an extensive background in genetic engineering and cell line development, is committed to providing innovative solutions that empower researchers to push the boundaries of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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